ArticleCrystal growth & design2024
Structure Determination of Biogenic Crystals Directly from 3D Electron Diffraction Data.
Article in Crystal growth & design, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- Semi-automated MicroED system unveils multiple polymorphs in fish-derived guanine crystals.Acta crystallographica. Section C, Structural chemistry · 2026Article
- Damselflies overcome color saturation barriers of photonic glasses via pigment loading and refractive index modulation.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Structural properties, polymorphism, and multiscale disorder unravel energy transport limitations in perylene diimide semiconductors.Science advances · 2026Article
- Control Strategies in Guanine Biocrystallization.Angewandte Chemie (International ed. in English) · 2026Review
- Nudibranch color diversity shares a common physical basis in guanine photonic structure 'pixels'.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Purine Molecular Interactions Determine Anisotropic Shape of Zebrafish Biogenic Crystals.Small methods · 2025Article
- Guanine Crystal Formation at Physiological pH.Crystal growth & design · 2025Article
- Guanine Crystallization by Particle Attachment.Journal of the American Chemical Society · 2025Article
- Revealing the Crystal Structure of the Purine Base Xanthine with Three-Dimensional (3D) Electron Diffraction.Crystal growth & design · 2025Article
- MicroED: Unveiling the Structural Chemistry of Plant Biomineralisation.Molecules (Basel, Switzerland) · 2024Article
- Rationalizing the Influence of Small-Molecule Dopants on Guanine Crystal Morphology.Chemistry of materials : a publication of the American Chemical Society · 2024Article
- Understanding the Solid-State Structure of Riboflavin through a Multitechnique Approach.Crystal growth & design · 2024Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Highly reflective assemblies of purine, pteridine, and flavin crystals are used in the coloration and visual systems of many different animals. However, structure determination of biogenic crystals by single-crystal XRD is challenging due to the submicrometer size and beam sensitivity of the crystals, and powder XRD is inhibited due to the small volumes of powders, crystalline impurity phases, and significant preferred orientation. Consequently, the crystal structures of many biogenic materials remain unknown. Herein, we demonstrate that the 3D electron diffraction (3D ED) technique provides a powerful alternative approach, reporting the successful structure determination of biogenic guanine crystals (from spider integument, fish scales, and scallop eyes) from 3D ED data confirmed by analysis of powder XRD data. The results show that all biogenic guanine crystals studied are the previously known β-polymorph. This study highlights the considerable potential of 3D ED for elucidating the structures of biogenic molecular crystals in the nanometer-to-micrometer size range. This opens up an important opportunity in the development of organic biomineralization, for which structural knowledge is critical for understanding the optical functions of biogenic materials and their possible applications as sustainable, biocompatible optical materials.
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Registered trials
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