ArticleNature cardiovascular research2023
Tbx5 maintains atrial identity in post-natal cardiomyocytes by regulating an atrial-specific enhancer network.
Erratum issuedOpen access · greenAbstract read
In one paragraph
Article in Nature cardiovascular research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 25 papers.
0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 26 citations in OpenAlex.
- Dose-dependent sensitivity of human three-dimensional chromatin to a heart disease-linked transcription factor.Science (New York, N.Y.) · 2026Article
- The cardiac 4D nucleome: nuclear and chromatin dynamics across development, disease and ageing.Nature reviews. Cardiology · 2026Review
- Organ-Specific and Conserved Regulatory Logic Orchestrates Gene Expression in the Embryonic Mesothelium.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Gene-gene interactions between a LMNA variant and common polymorphisms drive early-onset atrial fibrillation.Nature communications · 2026Article
- Cardiac epigenome in heart development and disease.Nature reviews. Cardiology · 2026Review
- A SWI/SNF-specific Ig-like domain, SWIFT, is a transcription factor binding platform.Science (New York, N.Y.) · 2026Article
- Antioxidant Astaxanthin Co-Treatment Protects Zebrafish from Dimethomorph-Induced Cardiovascular Toxicity.International journal of molecular sciences · 2026Article
- Single-Cell Multi-Omics Reveal Gene Regulatory Mechanisms Underlying Cardiac Embryonic Development.Genes · 2026Review
- Rejuvenating the damaged and aged heart: lessons from development.npj biomedical innovations · 2026Review
- Enhancer Dynamics for Gene Regulation in the Cardiovascular System.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- Profiling the epigenomic landscape of late embryonic and adult mouse hind limb muscles.Scientific reports · 2026Article
- A reduced TBX5-dependent gene regulatory network links atrial fibrillation and heart failure.Nature cardiovascular research · 2026Article
- Reduced TBX5 dosage undermines developmental control of atrial cardiomyocyte identity in a model of human atrial disease.Development (Cambridge, England) · 2026Article
- Enhancer Trajectories in Lineage Commitment: Regulatory Logic of States and Cooperation.Biomolecules · 2026Review
- Understanding normal cardiac morphogenesis and its disruptions: a journey through pathways.Frontiers in genetics · 2026Review
- Targeting SRPK3 Attenuates Cardiac Hypertrophy and Heart Failure by Improving Mitochondrial Bioenergetics through mRNA Splicing and Decay.Research (Washington, D.C.) · 2026Article
- PITX2 dosage-dependent changes in pacemaker cell state underlie sinus node dysfunction and atrial arrhythmias.Nature communications · 2025Article
- TBX5 and CHD4 Coordinately Activate Atrial Cardiomyocyte Genes to Maintain Cardiac Rhythm Homeostasis.Circulation · 2025Article
- Single-nuclei multiomics analysis identifies abnormal cardiomyocytes in a murine model of cardiac development.Nature communications · 2025Article
- SCIG: Machine learning uncovers cell identity genes in single cells by genetic sequence codes.Nucleic acids research · 2025Article
Corrections and comments
- Erratum issued
- Update of
Authors and funding
25 authors at 4 institutions in 3 countries.
Mason E SweatDepartment of Cardiology, Boston Children's Hospital, 300 Longwood Ave, Boston, MA 02115.
Yangpo CaoDepartment of Cardiology, Boston Children's Hospital, 300 Longwood Ave, Boston, MA 02115.
Xiaoran ZhangDepartment of Cardiology, Boston Children's Hospital, 300 Longwood Ave, Boston, MA 02115.
Ozanna Burnicka-TurekDepartment of Pediatrics, Pathology, and Human Genetics, The University of Chicago, Chicago, IL.
Carlos Perez-CervantesDepartment of Pediatrics, Pathology, and Human Genetics, The University of Chicago, Chicago, IL.
Kulandai ArulsamyDepartment of Cardiology, Boston Children's Hospital, 300 Longwood Ave, Boston, MA 02115.
Fujian LuDepartment of Cardiology, Boston Children's Hospital, 300 Longwood Ave, Boston, MA 02115.
Erin M KeatingDepartment of Cardiology, Boston Children's Hospital, 300 Longwood Ave, Boston, MA 02115.
Brynn N AkerbergDepartment of Cardiology, Boston Children's Hospital, 300 Longwood Ave, Boston, MA 02115.
Qing MaDepartment of Cardiology, Boston Children's Hospital, 300 Longwood Ave, Boston, MA 02115.
Hiroko WakimotoDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Joshua M GorhamDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Lauren D HillDepartment of Cardiology, Boston Children's Hospital, 300 Longwood Ave, Boston, MA 02115.
Mi Kyoung SongDepartment of Cardiology, Boston Children's Hospital, 300 Longwood Ave, Boston, MA 02115.
Michael A TrembleyDepartment of Cardiology, Boston Children's Hospital, 300 Longwood Ave, Boston, MA 02115.
Peizhe WangDepartment of Cardiology, Boston Children's Hospital, 300 Longwood Ave, Boston, MA 02115.
Matteo GianeselliDepartment of Cardiology, Boston Children's Hospital, 300 Longwood Ave, Boston, MA 02115.
Maksymilian ProndzynskiDepartment of Cardiology, Boston Children's Hospital, 300 Longwood Ave, Boston, MA 02115.
Raul H BortolinDepartment of Cardiology, Boston Children's Hospital, 300 Longwood Ave, Boston, MA 02115.
Vassilios J BezzeridesDepartment of Cardiology, Boston Children's Hospital, 300 Longwood Ave, Boston, MA 02115.
Kaifu ChenDepartment of Cardiology, Boston Children's Hospital, 300 Longwood Ave, Boston, MA 02115.
Jonathan G SeidmanDepartment of Pediatrics, Pathology, and Human Genetics, The University of Chicago, Chicago, IL.
Christine E SeidmanDepartment of Pediatrics, Pathology, and Human Genetics, The University of Chicago, Chicago, IL.
Ivan P MoskowitzDepartment of Pharmacology, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong 518055, China.
William T PuDepartment of Cardiology, Boston Children's Hospital, 300 Longwood Ave, Boston, MA 02115.
Boston Children's Hospital · USHarvard University · USUniversity of Chicago · USSouthern University of Science and Technology · CN
Funding
RESEARCH METHODS IN PEDIATRICS HEART DISEASET32HL007572 · NHLBI · CHILDREN'S HOSPITAL BOSTON · PI Sarah D DE FERRANTI, Jane W. Newburger · 1985 to 2026
$13.0MGenomic Effects on Right Ventricular Function, Clinical Features and Outcomes in CHDU01HL098147 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI NEWBURGER, JANE W., ROBERTS, AMY E · 2009 to 2024
$6.7MTranscriptional regulation of chamber selective gene expressionR01HL156503 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI William Tswenching Pu · 2021 to 2026
$4.0MReversal of Heart Failure: Role of Vascular RecoveryR01HL148338 · NHLBI · METHODIST HOSPITAL RESEARCH INSTITUTE · PI CHEN, KAIFU, COOKE, JOHN P · 2020 to 2023
$2.8MBioinformatics Techniques to Analyze Dynamic Changes of 3D GenomeR01GM138407 · NIGMS · BOSTON CHILDREN'S HOSPITAL · PI CHEN, KAIFU · 2022 to 2025
$1.8MRole of S-nitrosylation in TransdifferentiationR01HL133254 · NHLBI · METHODIST HOSPITAL RESEARCH INSTITUTE · PI CHEN, KAIFU, COOKE, JOHN P · 2018 to 2021
$1.6MComputational epigenetics modeling of cell identity genesR01GM125632 · NIGMS · METHODIST HOSPITAL RESEARCH INSTITUTE · PI CHEN, KAIFU · 2018 to 2021
$1.4MThe molecular determinants of atrial fibrillationR00HL173573 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI Mason Eric Sweat · 2025 to 2026
$498kThe molecular determinants of atrial fibrillationK99HL173573 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI SWEAT, MASON ERIC · 2024 to 2025
$246kTranscriptional mechanisms of atrial fibrillationF32HL163877 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI SWEAT, MASON ERIC · 2022 to 2023
$83kNHLBI NIH HHS F32 HL163877NHLBI NIH HHS K99 HL173573NHLBI NIH HHS R00 HL173573NHLBI NIH HHS R01 HL133254NHLBI NIH HHS R01 HL148338NHLBI NIH HHS R01 HL156503NHLBI NIH HHS T32 HL007572NHLBI NIH HHS U01 HL098147NIGMS NIH HHS R01 GM125632NIGMS NIH HHS R01 GM138407
Abstract
Understanding how the atrial and ventricular heart chambers maintain distinct identities is a prerequisite for treating chamber-specific diseases. Here, we selectively knocked out (KO) the transcription factor
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