Evidence map›Paper›PMID 38344177›Full record

ArticleFrontiers in pharmacology2024

Applying the estimand and target trial frameworks to external control analyses using observational data: a case study in the solid tumor setting.

Letizia Polito, Qixing Liang, Navdeep Pal, Philani Mpofu, Ahmed Sawas, Olivier Humblet, Kaspar Rufibach, Dominik Heinzmann

Abstract read
In one paragraph

Article in Frontiers in pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. On the use of external controls in clinical trials.Journal of the National Cancer Institute. Monographs · 2025
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Letizia Polito *Product Development Data Sciences, F Hoffmann-La Roche Ltd., Basel, Switzerland.
Qixing Liang *Flatiron Health, Inc., New York, NY, United States.
Navdeep PalGenentech, Inc., San Francisco, CA, United States.
Philani MpofuFlatiron Health, Inc., New York, NY, United States.
Ahmed SawasFlatiron Health, Inc., New York, NY, United States.
Olivier HumbletFlatiron Health, Inc., New York, NY, United States.
Kaspar RufibachProduct Development Data Sciences, F Hoffmann-La Roche Ltd., Basel, Switzerland.
Dominik HeinzmannProduct Development Data Sciences, F Hoffmann-La Roche Ltd., Basel, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

causal inferenceestimand frameworkexternal controloncologyreal-world datatarget trial emulation framework

Identifiers

PMID38344177
PMCPMC10853363

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.