Evidence map›Paper›PMID 38344174›Full record

ArticleFrontiers in pharmacology2024

Surgical procedure of intratympanic injection and inner ear pharmacokinetics simulation in domestic pigs.

Adele Moatti, Shannon Connard, Novietta De Britto, William A Dunn, Srishti Rastogi, Mani Rai, Lauren V Schnabel, Frances S Ligler, Kendall A Hutson, Douglas C Fitzpatrick and 3 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Round window membrane extracellular vesicles facilitate inner ear drug delivery.Journal of controlled release : official journal of the Controlled Release Society · 2025
    Article
  5. Drug selection for inner ear therapy.Frontiers in pharmacology · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Adele MoattiJoint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, North Carolina State University, Raleigh, NC, United States.
Shannon ConnardComparative Medicine Institute, North Carolina State University, Raleigh, NC, United States.
Novietta De BrittoJoint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, North Carolina State University, Raleigh, NC, United States.
William A DunnDepartment of Otolaryngology-Head and Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Srishti RastogiJoint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, North Carolina State University, Raleigh, NC, United States.
Mani RaiJoint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, North Carolina State University, Raleigh, NC, United States.
Lauren V SchnabelComparative Medicine Institute, North Carolina State University, Raleigh, NC, United States.
Frances S LiglerDepartment of Biomedical Engineering, Texas A&M University, College Station, TX, United States.
Kendall A HutsonDepartment of Otolaryngology-Head and Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Douglas C FitzpatrickDepartment of Otolaryngology-Head and Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Alec SaltTuner Scientific, Jacksonville, IL, United States.
Carlton J ZdanskiDepartment of Otolaryngology-Head and Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Alon GreenbaumJoint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, North Carolina State University, Raleigh, NC, United States.
University of North Carolina at Chapel Hill · USNorth Carolina State University · USTexas A&M University · US

Funding

Comparative Medicine and Translational Research Training ProgramT32OD011130 · OD · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI Lauren Virginia Schnabel · 2012 to 2026
$7.8M
Establishing the pig as a large animal model for studying drug delivery to the inner earR21DC020005 · NIDCD · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI GREENBAUM, ALON · 2022 to 2024
$570k
Enhanced intratympanic delivery of therapeutics to treat and prevent hearing loss using nanovesicles in the porcine modelK99DC019960 · NIDCD · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI MOATTI, ADELE · 2022 to 2023
$205k
NIDCD NIH HHS K99 DC019960NIDCD NIH HHS R21 DC020005NIH HHS T32 OD011130
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

fluid simulationinner earintratympanicpharmacokineticspigsround window membraneswine

Identifiers

PMID38344174
PMCPMC10853450
OpenAlexW4391261626

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.