Evidence map›Paper›PMID 38344110›Full record

ArticleFrontiers in neurology2023

Effect of body mass index on survival after spinal cord injury.

Nader Fallah, Vanessa K Noonan, Nancy P Thorogood, Brian K Kwon, Marcel A Kopp, Jan M Schwab

Erratum issuedAbstract read
In one paragraph

Article in Frontiers in neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Nader FallahPraxis Spinal Cord Institute, Blusson Spinal Cord Centre, Vancouver, BC, Canada.
Vanessa K NoonanPraxis Spinal Cord Institute, Blusson Spinal Cord Centre, Vancouver, BC, Canada.
Nancy P ThorogoodPraxis Spinal Cord Institute, Blusson Spinal Cord Centre, Vancouver, BC, Canada.
Brian K KwonDepartment of Orthopaedics, Vancouver Spine Surgery Institute, University of British Columbia, Vancouver, BC, Canada.
Marcel A KoppDepartment of Neurology and Experimental Neurology, Clinical and Experimental Spinal Cord Injury Research, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Jan M SchwabDepartment of Neurology and Experimental Neurology, Clinical and Experimental Spinal Cord Injury Research, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Funding

Reducing Infection Susceptibility by Immune Function Restoration in Spinal Cord InjuryR01NS118200 · NINDS · OHIO STATE UNIVERSITY · PI SCHWAB, JAN · 2020 to 2024
$1.9M
Protecting Endogenous Recovery from the "Infectious Insult" in Spinal Cord InjuryR01NS135237 · NINDS · OHIO STATE UNIVERSITY · PI Angela R Filous, Andrew Robert Sas · 2024 to 2026
$1.7M
ACL HHS 90SI5020NINDS NIH HHS R01 NS118200NINDS NIH HHS R01 NS135237
6 · The paper itself

Abstract

Introduction: Increased mortality after acute and chronic spinal cord injury (SCI) remains a challenge and mandates a better understanding of the factors contributing to survival in these patients. This study investigated whether body mass index (BMI) measured after acute traumatic SCI is associated with a change in mortality. Methods: A prospective longitudinal cohort study was conducted with 742 patients who were admitted to the Acute Spine Unit of the Vancouver General Hospital between 2004 and 2016 with a traumatic SCI. An investigation of the association between BMI on admission and long-term mortality was conducted using classification and regression tree (CART) and generalized additive models (spline curves) from acute care up to 7.7 years after SCI (chronic phase). Multivariable models were adjusted for (i) demographic factors (e.g., age, sex, and Charlson Comorbidity Index) and (ii) injury characteristics (e.g., neurological level and severity and Injury Severity Score). Results: After the exclusion of incomplete datasets ( Discussion: Mortality risk (1 month to 7.7 years after SCI) was associated with differences in BMI at admission. Further research is needed to better understand the underlying mechanisms. Given an established association of BMI with metabolic determinants, these results may suggest unknown neuro-metabolic pathways that are crucial for patient survival.

Indexed as

acute spinal cord injurybody mass indexCharlson comorbidity indexinjury severity scoremortality risk

Identifiers

PMID38344110
PMCPMC10853461

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.