Evidence map›Paper›PMID 38344043›Full record

ArticleGeburtshilfe und Frauenheilkunde2024

Nausea and Vomiting of Pregnancy and its Management with the Dual-Release Formulation of Doxylamine and Pyridoxine.

Ekkehard Schleußner, Susan Jäkel, Christoph Keck, Kirsten Kuhlmann, Mandy Mangler, Wolfgang E Paulus, Johanna Eiblwieser, Theresa Steeb, Pedro-Antonio Regidor

Open access · hybridAbstract read
In one paragraph

Article in Geburtshilfe und Frauenheilkunde, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Ekkehard SchleußnerKlinik für Geburtsmedizin, Universitätsklinikum Jena, Jena, Germany.
Susan JäkelFrauenarztpraxis Gera, Gera, Germany.
Christoph KeckMedicover Laborgruppe Deutschland, Berlin, Germany.
Kirsten KuhlmannFrauenarztpraxis Berlin, Berlin, Germany.
Mandy ManglerKlinik für Gynäkologie und Geburtsmedizin, Vivantes Auguste-Viktoria-Klinikum, Berlin, Germany.
Wolfgang E PaulusKlinik für Frauenheilkunde und Geburtshilfe, Universitätsklinikum Ulm, Ulm, Germany.
Johanna EiblwieserExeltis Germany GmbH, Ismaning, Germany.
Theresa SteebExeltis Germany GmbH, Ismaning, Germany.
Pedro-Antonio RegidorExeltis Healthcare, Ismaning, Germany.ORCID 0000-0002-9551-2847
Auguste-Viktoria-Klinik · DEJena University Hospital · DEKlinik für Frauenheilkunde · DEMedicover · DESRH Wald-Klinikum Gera · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nausea and vomiting of pregnancy (NVP) is among the most common conditions that pregnant women encounter in the early stages of pregnancy. It can affect up to 85% of pregnant women, thus representing a significant public health concern. NVP results in substantial negative physical, emotional, and financial consequences. Despite its prevalence, the pathogenesis remains elusive. Few guidelines have been published; however, several interventions exist for the symptomatic treatment of NVP. The aim of this review is to provide an overview of modern treatment strategies of NVP with a special focus on the recently approved dual-release formulation of the doxylamine and pyridoxine combination. This combination was approved by the Food and Drug Administration (FDA) in November 2016 for the treatment of NVP when conservative management fails, and it has been introduced to the American market in April 2018. The maximum plasma concentration (T

Indexed as

doxylamineemesisnausea and vomiting of pregnancypregnancypyridoxine

Identifiers

PMID38344043
PMCPMC10853031
OpenAlexW4391659394

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.