Evidence map›Paper›PMID 38343879›Full record

ArticleRegenerative biomaterials2024

Vascular endothelial cellular mechanics under hyperglycemia and its role in tissue regeneration.

Kui Wang, Yongmei Ge, Yongshuai Yang, Zhenjian Li, Jiayi Liu, Yizebang Xue, Yuanjun Zhang, Xiangchao Pang, A H W Ngan, Bin Tang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Regenerative biomaterials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Synergistic Effect of Banaba Leaf Extract and Policosanol (RaydelPharmaceuticals (Basel, Switzerland) · 2025
    Article
  9. Article
  10. Synergistic Efficacy of Policosanol (RaydelPharmaceuticals (Basel, Switzerland) · 2025
    Article
  11. Article
  12. Article
  13. Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Kui WangDepartment of Biomedical Engineering, Southern University of Science and Technology, Shenzhen 518055, China.
Yongmei GeDepartment of Biomedical Engineering, Southern University of Science and Technology, Shenzhen 518055, China.
Yongshuai YangDepartment of Biomedical Engineering, Southern University of Science and Technology, Shenzhen 518055, China.
Zhenjian LiDepartment of Biomedical Engineering, Southern University of Science and Technology, Shenzhen 518055, China.
Jiayi LiuDepartment of Biomedical Engineering, Southern University of Science and Technology, Shenzhen 518055, China.
Yizebang XueDepartment of Biomedical Engineering, Southern University of Science and Technology, Shenzhen 518055, China.
Yuanjun ZhangDepartment of Biomedical Engineering, Southern University of Science and Technology, Shenzhen 518055, China.
Xiangchao PangGuangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment, Shenzhen 518055, China.
A H W NganDepartment of Mechanical Engineering, University of Hong Kong, Hong Kong 999077, China.
Bin TangDepartment of Biomedical Engineering, Southern University of Science and Technology, Shenzhen 518055, China.
Southern University of Science and Technology · CNUniversity of Hong Kong · HKCentral South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetes is one of the most prevalent diseases worldwide. The tissue regeneration of diabetes patients is known to be rather tricky as the result of vascular dysfunction, and this leads to various clinical complications including diabetic foot ulcers. The vascular endothelial cells, which compactly line the inner surface of blood vessels, are responsible for the growth and maintenance of blood vessels and play an essential role in tissue regeneration. Although the mechanical properties of cells are generally known to be regulated by physiological/pathological conditions, few studies have been performed to investigate vascular endothelial cellular mechanics under hyperglycemia and the biological functions related to tissue regeneration. In this study, we conduct a systematic investigation of this issue. The results suggested that the stiffness of human umbilical vein endothelial cells (HUVECs) can be significantly regulated by the glucose concentration, subsequently, leading to significant alterations in cell migration and proliferation capabilities that are closely related to tissue regeneration. The rearrangement of the cytoskeleton induced by hyperglycemia through Cdc42 was found to be one of the pathways for the alteration of the cell stiffness and the subsequent cell dysfunctions. Therefore, we suggested that the inhibition of Cdc42 might be a promising strategy to facilitate various tissue regeneration for diabetes patients.

Indexed as

Cdc42endothelial cellhyperglycemiamigrationstiffness

Identifiers

PMID38343879
PMCPMC10858347
OpenAlexW4391260512

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.