ArticleResearch square2024
The effect of sexual behavior on HIV-1 seroconversion is mediated by the gut microbiome and proinflammatory cytokines.
Huang Lin, Yue Chen, Grace Abror, Meaghan Price, Alison Morris, Jing Sun, Frank Palella, Kara W Chew, Todd T Brown, Charles R Rinaldo and 1 more
Open access · greenAbstract readPreprint
In one paragraphArticle in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
11 authors at 6 institutions in 1 country.
Yue ChenCo-first authors.
Grace AbrorDepartment of Infectious Diseases and Microbiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA USA.
Meaghan PriceDepartment of Infectious Diseases and Microbiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA USA.
Alison MorrisDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA USA.
Jing SunDepartment of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD USA.ORCID 0000-0003-3741-0962 Frank PalellaDepartment of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL USA.
Todd T BrownDepartment of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD USA.
Charles R RinaldoCo-senior authors.
University of Pittsburgh · USJohns Hopkins University · USHealth First · USNational Institute of Environmental Health Sciences · USNorthwestern University · USUniversity of California, Los Angeles · US
Funding
Clinical Research Sites for the MACS/WIHS Combined Cohort Study (MACS/WIHS-CCS) - Baltimore/Wash DC Center - Admin Supplement: Vision and dual sensory loss in HIV-infected older adultsU01HL146201 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI TODD T BROWN, Joseph B. Margolick · 2019 to 2026
$33.7MSex differences in the role of multi-omics in HIV-associated carotid artery atherosclerosisU01HL146204 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI David B. Hanna, Anjali Sharma · 2019 to 2026
$33.2MUniversity of Pittsburgh MWCCS Clinical Research SiteU01HL146208 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Bernard Jonas C Macatangay, CHARLES R RINALDO · 2019 to 2026
$32.2MNorthwestern CORE Clinical Research Site: Trans-omics for HIV/AIDS ResearchU01HL146240 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Frank J Palella, Valentina Stosor · 2019 to 2026
$31.5MCollaborative Biostatistical ResearchZIAES103390 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI PEDDADA, SHYAMAL · 2023 to 2025
$665kBringing Untargeted Metabolomics to PittS10OD023402 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GELHAUS, STACY LYNN · 2018 to 2018
$594kIntramural NIH HHS ZIA ES103390NHLBI NIH HHS U01 HL146201NHLBI NIH HHS U01 HL146204NHLBI NIH HHS U01 HL146208NHLBI NIH HHS U01 HL146240NIH HHS S10 OD023402
6 · The paper itselfAbstract
The association between HIV-1 seroconversion and gut dysbiosis is well documented, and its association with sexual activity is also widely recognized. However, it is not known whether the gut dysbiosis mediates the effects of high-risk sexual behavior on HIV-1 seroconversion. In this report we focused on men who engaged in high-risk sexual behavior where they had receptive anal intercourse with multiple men. We demonstrate that proinflammatory cytokines, sCD14 and sCD163, and gut microbiota mediate the effects of this high-risk sexual behavior on subsequent HIV seroconversion. We discovered changes in the gut microbial ecology, prior to seroconversion, both in terms of the composition as well as inter-relationships among the commensal species. Furthermore, these changes correlate with future HIV seroconversion. Specifically, as the number of sexual partners increased, we discovered in a "dose-response" manner, a decrease in the abundance of commensal and short-chain fatty acid-producing species,
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PMID38343862
PMCPMC10854284
OpenAlexW4391175863
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