Evidence map›Paper›PMID 38343848›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Blood Cholesterol and Triglycerides Associate with Right Ventricular Function in Pulmonary Hypertension.

Battoul Fakhry, Laura Peterson, Suzy A A Comhair, Jacqueline Sharp, Margaret M Park, W H Wilson Tang, Donald R Neumann, Frank P DiFilippo, Samar Farha, Serpil C Erzurum and 1 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Battoul FakhryLerner Research Institute, Cleveland Clinic, Cleveland, OH, United States.ORCID 0000-0002-4600-1573
Laura PetersonLerner Research Institute, Cleveland Clinic, Cleveland, OH, United States.
Suzy A A ComhairLerner Research Institute, Cleveland Clinic, Cleveland, OH, United States.
Jacqueline SharpLerner Research Institute, Cleveland Clinic, Cleveland, OH, United States.
Margaret M ParkHeart Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, OH, United States.
W H Wilson TangHeart Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, OH, United States.
Donald R NeumannImaging Institute, Cleveland Clinic, Cleveland, OH, United States.
Frank P DiFilippoImaging Institute, Cleveland Clinic, Cleveland, OH, United States.
Samar FarhaLerner Research Institute, Cleveland Clinic, Cleveland, OH, United States.
Serpil C ErzurumLerner Research Institute, Cleveland Clinic, Cleveland, OH, United States.
Anny MulyaLerner Research Institute, Cleveland Clinic, Cleveland, OH, United States.ORCID 0000-0002-6008-1514
Cleveland Clinic · USCleveland Clinic Lerner College of Medicine · US

Funding

Clinical and Translational Science Collaborative of ClevelandUL1TR002548 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI MCCOMSEY, GRACE A · 2018 to 2022
$35.5M
Clinical and Translational Science Collaborative of Northern Ohio, Catalyzing Linkages to Equity in Health (CLE Health)UM1TR004528 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI GRACE A MCCOMSEY · 2023 to 2026
$32.1M
NITRIC OXIDE PRODUCTION AND REACTIONS IN THE LUNGR01HL060917 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI Serpil C. Erzurum · 1999 to 2026
$6.3M
Pulmonary Vascular-Right Ventricular Axis Research ProgramR01HL115008 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI ERZURUM, SERPIL C., PRASAD, SATHYAMANGLA V · 2012 to 2016
$3.1M
NCATS NIH HHS UL1 TR002548NCATS NIH HHS UM1 TR004528NHLBI NIH HHS R01 HL060917NHLBI NIH HHS R01 HL115008
6 · The paper itself

Abstract

Background: Blood lipids are dysregulated in pulmonary hypertension (PH). Lower high-density lipoproteins cholesterol (HDL-C) and low-density lipoproteins cholesterol (LDL-C) are associated with disease severity and death in PH. Right ventricle (RV) dysfunction and failure are the major determinants of morbidity and mortality in PH. This study aims to test the hypothesis that dyslipidemia is associated with RV dysfunction in PH. Methods: We enrolled healthy control subjects (n=12) and individuals with PH (n=30) (age: 18-65 years old). Clinical characteristics, echocardiogram, 2-[18F] fluoro-2-deoxy-D-glucose positron emission tomography (PET) scan, blood lipids, including total cholesterol (TC), triglycerides (TG), lipoproteins (LDL-C and HDL-C), and N-terminal pro-B type Natriuretic Peptide (NT-proBNP) were determined. Results: Individuals with PH had lower HDL-C [PH, 41±12; control, 56±16 mg/dL, Conclusion: These findings confirm dyslipidemia is associated with worse right ventricular function in PH.

Indexed as

Circulating lipid and lipoproteinsDyslipidemiaPulmonary hypertensionRight ventricle failure

Identifiers

PMID38343848
PMCPMC10854346
OpenAlexW4391090548

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.