Evidence map›Paper›PMID 38343844›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Associations of plasma omega-6 and omega-3 fatty acids with overall and 19 site-specific cancers: a population-based cohort study in UK Biobank.

Yuchen Zhang, Yitang Sun, Suhang Song, Nikhil K Khankari, J Thomas Brenna, Ye Shen, Kaixiong Ye

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Yuchen ZhangDepartment of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens, Georgia, US.ORCID 0000-0002-8992-5258
Yitang SunDepartment of Genetics, University of Georgia, Athens, Georgia, US.ORCID 0000-0002-6564-8815
Suhang SongDepartment of Health Policy and Management, College of Public Health, University of Georgia, Athens, Georgia, US.ORCID 0000-0003-1934-632X
Nikhil K KhankariDivision of Genetic Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, US.ORCID 0000-0002-8802-4431
J Thomas BrennaDivision of Nutritional Sciences, Cornell University, Ithaca, NY, US.ORCID 0000-0001-9494-4245
Ye ShenDepartment of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens, Georgia, US.ORCID 0000-0002-6662-0048
Kaixiong YeDepartment of Genetics, University of Georgia, Athens, Georgia, US.ORCID 0000-0003-4658-7292
University of Georgia · USCornell University · USVanderbilt University Medical Center · US

Funding

Gene-Environment Interactions in Human Evolution and Complex TraitsR35GM143060 · NIGMS · UNIVERSITY OF GEORGIA · PI YE, KAIXIONG · 2021 to 2025
$1.9M
Medical Research Council MC_PC_20058NIGMS NIH HHS R35 GM143060
6 · The paper itself

Abstract

Background: Previous epidemiological studies of the associations between polyunsaturated fatty acids (PUFAs) and cancer incidence have been inconsistent. We investigated the associations of plasma omega-3 and omega-6 PUFAs with the incidence of overall and 19 site-specific cancers in a large prospective cohort. Methods: 253,138 eligible UK Biobank participants were included in our study. With a mean follow-up of 12.9 years, 29,838 participants were diagnosed with cancer. The plasma levels of omega-3 and omega-6 PUFAs were expressed as percentages of total fatty acids (omega-3% and omega-6%). Results: In our main models, both omega-6% and omega-3% were inversely associated with overall cancer incidence (HR per SD = 0.98, 95% CI = 0.96-0.99; HR per SD = 0.99, 95% CI = 0.97-1.00; respectively). Of the 19 site-specific cancers available, 14 were associated with omega-6% and five with omega-3%, all indicating inverse associations, with the exception that prostate cancer was positively associated with omega-3% (HR per SD = 1.03, 95% CI = 1.01 - 1.05). Conclusions: Our population-based cohort study in UK Biobank indicates small inverse associations of plasma omega-6 and omega-3 PUFAs with the incidence of overall and most site-specific cancers, although there are notable exceptions, such as prostate cancer.

Indexed as

Cancer incidenceOmega-3 fatty acidsOmega-6 fatty acidsPolyunsaturated fatty acidsProspective cohort study

Identifiers

PMID38343844
PMCPMC10854355
OpenAlexW4391090638

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.