Evidence map›Paper›PMID 38343796›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Genetic polymorphism and evidence of signatures of selection in the

Beatus M Lyimo, Catherine Bakari, Zachary R Popkin-Hall, David J Giesbrecht, Misago D Seth, Dativa Pereus, Ramadhan Moshi, Ruth Boniface, Celine I Mandara, Rashid Madebe and 3 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 3 countries.

Beatus M LyimoNational Institute for Medical Research, Dar es Salaam, Tanzania.
Catherine BakariNational Institute for Medical Research, Dar es Salaam, Tanzania.ORCID 0000-0002-8710-1765
Zachary R Popkin-HallUniversity of North Carolina, Chapel Hill, NC, USA.
David J GiesbrechtBrown University, Providence, RI, USA.ORCID 0000-0003-2498-4705
Misago D SethNational Institute for Medical Research, Dar es Salaam, Tanzania.
Dativa PereusNational Institute for Medical Research, Dar es Salaam, Tanzania.
Ramadhan MoshiNational Institute for Medical Research, Dar es Salaam, Tanzania.
Ruth BonifaceNational Institute for Medical Research, Dar es Salaam, Tanzania.
Celine I MandaraNational Institute for Medical Research, Dar es Salaam, Tanzania.
Rashid MadebeNational Institute for Medical Research, Dar es Salaam, Tanzania.
Jonathan J JulianoUniversity of North Carolina, Chapel Hill, NC, USA.
Jeffrey A BaileyBrown University, Providence, RI, USA.
Deus S IshengomaNational Institute for Medical Research, Dar es Salaam, Tanzania.
National Institute for Medical Research · TZJohn Brown University · USMuhimbili University of Health and Allied Sciences · TZUniversity of North Carolina at Chapel Hill · USHarvard University · US

Funding

Mentoring in Translational Malaria GenomicsK24AI134990 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Jonathan J Juliano · 2018 to 2026
$1.6M
NIAID NIH HHS K24 AI134990Wellcome Trust
6 · The paper itself

Abstract

Background: In 2021 and 2023, the World Health Organization approved RTS, S/AS01 and R21/Matrix M malaria vaccines, respectively, for routine immunization of children in African countries with moderate to high transmission. These vaccines are made of Methods: The analysis involved 589 whole genome sequences generated by and as part of the MalariaGEN Community Project. The samples were collected between 2013 and January 2015 from five regions of mainland Tanzania: Morogoro and Tanga (Muheza) (moderate transmission areas), and Kagera (Muleba), Lindi (Nachingwea), and Kigoma (Ujiji) (high transmission areas). Wright's inbreeding coefficient (F Results: Based on F Conclusions: The findings demonstrate high diversity of the

Indexed as

Circumsporozoite proteingenetic diversitymalaria vaccinePlasmodium falciparumsignature of selectionTanzania

Identifiers

PMID38343796
PMCPMC10854334
OpenAlexW4391172096

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.