Evidence map›Paper›PMID 38343771›Full record

ArticleJournal of tissue engineering

Adipose tissue derived stem cell secretome induces motor and histological gains after complete spinal cord injury in

Rita C Assunção-Silva, Andreia Pinho, Jorge R Cibrão, Inês M Pereira, Susana Monteiro, Nuno A Silva, Jonas Campos, Ana L Rebelo, Gerhard Schlosser, Luisa Pinto and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of tissue engineering. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Rita C Assunção-SilvaLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
Andreia PinhoLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
Jorge R CibrãoLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
Inês M PereiraLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
Susana MonteiroLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
Nuno A SilvaLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
Jonas CamposLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.ORCID https://orcid.org/0000-0001-8487-6621
Ana L RebeloCÚRAM, SFI Research Center for Medical Devices, National University of Ireland, Galway, Ireland.
Gerhard SchlosserCÚRAM, SFI Research Center for Medical Devices, National University of Ireland, Galway, Ireland.
Luisa PintoLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
Abhay PanditCÚRAM, SFI Research Center for Medical Devices, National University of Ireland, Galway, Ireland.ORCID https://orcid.org/0000-0002-6292-4933
António J SalgadoLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
University of Minho · PTOllscoil na Gaillimhe – University of Galway · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mesenchymal stem cell-based therapies have been studied for spinal cord injury (SCI) treatment due to their paracrine action upon damaged tissues. MSCs neuroregenerative role may relate to the contents of their secretome in anti-inflammatory cytokines and growth-permissive factors. We propose using the secretome of MSCs isolated from the adipose tissue-adipose tissue-derived stem cells (ASCs) as a cell-free based therapy for SCI. In vivo studies were conducted in two SCI models,

Indexed as

adipose tissue derived stem cellaxonal growthmouse modelneuroinflammationregenerationsecretomeSpinal cord injuryXenopus laevis

Identifiers

PMID38343771
PMCPMC10858666
OpenAlexW4391696426

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.