Evidence map›Paper›PMID 38343606›Full record

ArticleJournal of clinical and translational hepatology2024

Comprehensive Bile Acid Profiling of ABCB4-mutated Patients and the Prognostic Role of Taurine-conjugated 3α,6α,7α,12α-Tetrahydroxylated Bile Acid in Cholestasis.

Teng Liu, Ren-Xue Wang, Jun Han, Zhong-Die Li, Jonathan A Sheps, Li-Juan Zheng, Xiao-Xiao Xu, Victor Ling, Jian-She Wang

Abstract read
In one paragraph

Article in Journal of clinical and translational hepatology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Bile acid signaling in health and disease.Molecular biomedicine · 2026
    Review
  2. ATP-binding Cassette Transporter Defects and Their Roles in Hepatic Diseases.Journal of clinical and translational hepatology · 2026
    Review
  3. Review
  4. Article
  5. Article
  6. [Progress in the treatment of progressive familial intrahepatic cholestasis].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2024
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Teng LiuDepartment of Pediatrics, Shanghai Medical College, Fudan University, The Center for Pediatric Liver Diseases, Children's Hospital of Fudan University, Shanghai, China.
Ren-Xue WangBC Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada.
Jun HanUniversity of Victoria-Genome BC Proteomics Center, University of Victoria, Victoria, British Columbia V8Z 7X8, Canada.
Zhong-Die LiDepartment of Pediatrics, Shanghai Medical College, Fudan University, The Center for Pediatric Liver Diseases, Children's Hospital of Fudan University, Shanghai, China.
Jonathan A ShepsBC Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada.
Li-Juan ZhengDepartment of Pediatrics, Shanghai Medical College, Fudan University, The Center for Pediatric Liver Diseases, Children's Hospital of Fudan University, Shanghai, China.
Xiao-Xiao XuDepartment of Pediatrics, Shanghai Medical College, Fudan University, The Center for Pediatric Liver Diseases, Children's Hospital of Fudan University, Shanghai, China.
Victor LingBC Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada.
Jian-She WangDepartment of Pediatrics, Shanghai Medical College, Fudan University, The Center for Pediatric Liver Diseases, Children's Hospital of Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0003-0823-586X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Aims: We asked if comprehensive bile acid profiling could provide insights into the physiopathology of Methods: Serum bile acid profiles were evaluated in 13 Results: The overall hydrophobicity indices of bile acids in Conclusions: Tauro-THBA concentration may be a biomarker for predicting the clinical outcome in low gamma-glutamyl transferase intrahepatic cholestasis patients.

Indexed as

Bile acidsBSEPLiquid chromatography-mass spectrometryMDR3PFIC

Identifiers

PMID38343606
PMCPMC10851069

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.