Evidence map›Paper›PMID 38343385›Full record

ArticleJournal of dental research2024

Murine IRF8 Mutation Offers New Insight into Osteoclast and Root Resorption.

A Das, S K Yesupatham, D Allison, H Tanwar, J Gnanasekaran, B Kear, X Wang, S Wang, C Zachariadou, Y Abbasi and 5 more

Open access · greenAbstract read
In one paragraph

Article in Journal of dental research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Integrative single-cell RNA-seq and ATAC-seq identifies transcriptional and epigenetic blueprint guiding osteoclastogenic trajectory.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025
    Article
  6. Article
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

A DasDivision of Periodontology, University of Maryland School of Dentistry, Baltimore, MD, USA.
S K YesupathamDivision of Periodontology, University of Maryland School of Dentistry, Baltimore, MD, USA.
D AllisonDivision of Periodontology, University of Maryland School of Dentistry, Baltimore, MD, USA.
H TanwarDivision of Periodontology, University of Maryland School of Dentistry, Baltimore, MD, USA.
J GnanasekaranDivision of Periodontology, University of Maryland School of Dentistry, Baltimore, MD, USA.
B KearDivision of Periodontology, University of Maryland School of Dentistry, Baltimore, MD, USA.
X WangDivision of Periodontology, University of Maryland School of Dentistry, Baltimore, MD, USA.
S WangDepartment of Neural and Pain Sciences, University of Maryland School of Dentistry, Baltimore, MD, USA.
C ZachariadouDivision of Biosciences, College of Dentistry, The Ohio State University, Columbus, OH, USA.
Y AbbasiDepartment of Neural and Pain Sciences, University of Maryland School of Dentistry, Baltimore, MD, USA.
M K ChungDepartment of Neural and Pain Sciences, University of Maryland School of Dentistry, Baltimore, MD, USA.ORCID 0000-0001-7637-1148
K OzatoEunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD, USA.
C LiuTransgenic Core, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA.
B L FosterDivision of Biosciences, College of Dentistry, The Ohio State University, Columbus, OH, USA.ORCID 0000-0003-3444-0576
V Thumbigere-MathDivision of Periodontology, University of Maryland School of Dentistry, Baltimore, MD, USA.
University of Maryland, Baltimore · USThe Ohio State University · USEunice Kennedy Shriver National Institute of Child Health and Human Development · USNational Heart Lung and Blood Institute · US

Funding

Trigeminal nociceptors: Neural intersection of chronic pain and alveolar bone remodelingR35DE030045 · NIDCR · UNIVERSITY OF MARYLAND BALTIMORE · PI Man-Kyo Chung · 2020 to 2026
$7.1M
Functions of extracellular matrix proteins in dental and skeletal mineralizationR01DE027639 · NIDCR · OHIO STATE UNIVERSITY · PI Brian Lee Foster · 2019 to 2026
$2.3M
The Role of Interferon Regulatory Factor 8 (IRF8) in Periodontal DiseaseR00DE028439 · NIDCR · UNIVERSITY OF MARYLAND BALTIMORE · PI THUMBIGERE-MATH, VIVEK · 2018 to 2020
$747k
The Interconnection between Mouth and Gut: Understanding the Microbial and Host Factors Influencing Susceptibility to Periodontitis and ColitisR56DK131277 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI THUMBIGERE-MATH, VIVEK · 2021 to 2021
$451k
Conditional Deletion of Irf8 in Monocyte Macrophage Lineage Provides Novel Insight into Irf8s Important Function in Osteoclast Regulation and Bone MetabolismR03DE029258 · NIDCR · UNIVERSITY OF MARYLAND BALTIMORE · PI THUMBIGERE-MATH, VIVEK · 2020 to 2021
$309k
NIDCR NIH HHS R00 DE028439NIDCR NIH HHS R01 DE027639NIDCR NIH HHS R03 DE029258NIDCR NIH HHS R35 DE030045NIDDK NIH HHS R56 DK131277
6 · The paper itself

Abstract

Interferon regulatory factor 8 (IRF8), a transcription factor expressed in immune cells, functions as a negative regulator of osteoclasts and helps maintain dental and skeletal homeostasis. Previously, we reported that a novel mutation in the

Indexed as

Bone ResorptionInterferon Regulatory FactorsRoot ResorptionAnimalsCell DifferentiationHumansInterferon Regulatory Factor-8MiceMutationNFATC Transcription FactorsOsteoclastsRANK LigandInterferon Regulatory Factor-8Interferon Regulatory FactorsNFATC Transcription FactorsRANK Liganddental biologygenetic animal modelsgenetic mutationhuman association studiesNFATC Transcription Factorsosteoclasts

Identifiers

PMID38343385
PMCPMC10985390
OpenAlexW4391752392

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.