ArticleJournal of cachexia, sarcopenia and muscle2024
Bed-rest and exercise remobilization: Concurrent adaptations in muscle glucose and protein metabolism.
Article in Journal of cachexia, sarcopenia and muscle, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 19 citations in OpenAlex.
- Musculoskeletal decay and bone-muscle crosstalk during physical disuse: Mechanisms and integrated countermeasures.Experimental physiology · 2026Review
- Pathological changes and therapeutic strategies for sarcopenia.EFORT open reviews · 2026Review
- The effects of bed rest on cardiometabolic health: A systematic review and meta-analysis.Experimental physiology · 2026Article
- Skeletal muscle protein turnover and mitochondrial responses to omega-3 fatty acid supplementation: an update.Current opinion in clinical nutrition and metabolic care · 2026Review
- Quantifying the Toll of Disuse: A Meta-Analysis of Skeletal Muscle Mass and Strength Loss Following Upper Limb Immobilization.Journal of clinical medicine · 2025Review
- Muscle preservation during hospitalization: energy balance, protein intake, and habitual physical activity.Current opinion in clinical nutrition and metabolic care · 2025Review
- The effect of bed rest, unilateral limb immobilization and head-down tilt on muscle protein synthesis: A systematic review and meta-analysis.Experimental physiology · 2025Review
- Integrated muscle protein synthesis during disuse and rehabilitation in late-midlife adults.American journal of physiology. Regulatory, integrative and comparative physiology · 2025Article
- Unilateral electrical stimulation of mice induces transcriptional response in stimulated leg with limited effect on non-stimulated contralateral leg.Experimental physiology · 2025Article
- Investigating muscle protein synthesis using deuterium oxide: The impact of dietary protein interventions across the lifespan.Experimental physiology · 2025Review
- Reprogramming metabolic gene expression during active recovery following disuse.The Journal of physiology · 2025Article
- Nutritional Interventions to Attenuate Quadriceps Muscle Deficits following Anterior Cruciate Ligament Injury and Reconstruction.Sports medicine (Auckland, N.Z.) · 2025Review
- Turning over new ideas in human skeletal muscle proteostasis: What do we know and where to from here?Experimental physiology · 2025Review
- Dietary proteins, amino acids and insulin resistance: a mini review.Frontiers in nutrition · 2025Review
- Skeletal muscle immobilisation-induced atrophy: mechanistic insights from human studies.Clinical science (London, England : 1979) · 2024Review
- Bed-rest and exercise remobilization: Concurrent adaptations in muscle glucose and protein metabolism.Journal of cachexia, sarcopenia and muscle · 2024Article
Corrections and comments
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Authors and funding
15 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundBed-rest (BR) of only a few days duration reduces muscle protein synthesis and induces skeletal muscle atrophy and insulin resistance, but the scale and juxtaposition of these events have not been investigated concurrently in the same individuals. Moreover, the impact of short-term exercise-supplemented remobilization (ESR) on muscle volume, protein turnover and leg glucose uptake (LGU) in humans is unknown.
methodsTen healthy males (24 ± 1 years, body mass index 22.7 ± 0.6 kg/m
resultsCompared with before BR, there was a 45% decline in insulin-stimulated LGU (P < 0.05) after BR, which was paralleled by a reduction in insulin-stimulated leg blood flow (P < 0.01) and removal of insulin-stimulated muscle glycogen storage. These events were accompanied by a 43% reduction in myofibrillar protein FSR (P < 0.05) and a 2.5% decrease in LMV (P < 0.01) during BR, along with a 30% decline in whole-body MPB after 2 days of BR (P < 0.05). Myofibrillar protein FSR and LMV were restored by 3 days of ESR (P < 0.01 and P < 0.01, respectively) but not by ambulation alone. However, insulin-stimulated LGU and muscle glycogen storage were not restored by ESR.
conclusionsThree days of BR caused concurrent reductions in LMV, myofibrillar protein FSR, myofibrillar protein breakdown and insulin-stimulated LGU, leg blood flow and muscle glycogen storage in healthy, young volunteers. Resistance ESR restored LMV and myofibrillar protein FSR, but LGU and muscle glycogen storage remained depressed, highlighting divergences in muscle fuel and protein metabolism. Furthermore, ambulation alone did not restore LMV and myofibrillar protein FSR in the non-exercised contralateral limb, emphasizing the importance of exercise rehabilitation following even short-term BR.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.