Evidence map›Paper›PMID 38343196›Full record

SynthesisActa neuropsychiatrica2024

Effects of electroconvulsive therapy on cortical thickness in depression: a systematic review.

Tommaso Toffanin, Giulia Cattarinussi, Niccolò Ghiotto, Marialaura Lussignoli, Chiara Pavan, Luca Pieri, Sami Schiff, Francesco Finatti, Francesca Romagnolo, Federica Folesani and 8 more

Open access · hybridAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Acta neuropsychiatrica, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 2 countries.

Tommaso ToffaninDepartment of Neuroscience and Rehabilitation, Institute of Psychiatry, University of Ferrara, Ferrara, Italy.
Giulia CattarinussiDepartment of Neuroscience (DNS), University of Padova, Padua, Italy.ORCID https://orcid.org/0000-0002-3063-2266
Niccolò GhiottoDepartment of Neuroscience (DNS), University of Padova, Padua, Italy.
Marialaura LussignoliDepartment of Neuroscience (DNS), University of Padova, Padua, Italy.
Chiara PavanDepartment of Neuroscience (DNS), University of Padova, Padua, Italy.
Luca PieriDepartment of Medicine, University of Padova, Padua, Italy.
Sami SchiffDepartment of Medicine, University of Padova, Padua, Italy.
Francesco FinattiDepartment of Neuroscience (DNS), University of Padova, Padua, Italy.
Francesca RomagnoloDepartment of Neuroscience and Rehabilitation, Institute of Psychiatry, University of Ferrara, Ferrara, Italy.
Federica FolesaniDepartment of Neuroscience and Rehabilitation, Institute of Psychiatry, University of Ferrara, Ferrara, Italy.
Maria Giulia NanniDepartment of Neuroscience and Rehabilitation, Institute of Psychiatry, University of Ferrara, Ferrara, Italy.
Rosangela CarusoDepartment of Neuroscience and Rehabilitation, Institute of Psychiatry, University of Ferrara, Ferrara, Italy.
Luigi ZerbinatiDepartment of Neuroscience and Rehabilitation, Institute of Psychiatry, University of Ferrara, Ferrara, Italy.
Martino Belvederi MurriDepartment of Neuroscience and Rehabilitation, Institute of Psychiatry, University of Ferrara, Ferrara, Italy.
Maria FerraraDepartment of Neuroscience and Rehabilitation, Institute of Psychiatry, University of Ferrara, Ferrara, Italy.
Giorgio PigatoDepartment of Psychiatry, Padova University Hospital, Padua, Italy.
Luigi GrassiDepartment of Neuroscience and Rehabilitation, Institute of Psychiatry, University of Ferrara, Ferrara, Italy.
Fabio SambataroDepartment of Neuroscience (DNS), University of Padova, Padua, Italy.
University of Ferrara · ITUniversity of Padua · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveElectroconvulsive therapy (ECT) is one of the most studied and validated available treatments for severe or treatment-resistant depression. However, little is known about the neural mechanisms underlying ECT. This systematic review aims to critically review all structural magnetic resonance imaging studies investigating longitudinal cortical thickness (CT) changes after ECT in patients with unipolar or bipolar depression.

methodsWe performed a search on PubMed, Medline, and Embase to identify all available studies published before April 20, 2023. A total of 10 studies were included.

resultsThe investigations showed widespread increases in CT after ECT in depressed patients, involving mainly the temporal, insular, and frontal regions. In five studies, CT increases in a non-overlapping set of brain areas correlated with the clinical efficacy of ECT. The small sample size, heterogeneity in terms of populations, comorbidities, and ECT protocols, and the lack of a control group in some investigations limit the generalisability of the results.

conclusionsOur findings support the idea that ECT can increase CT in patients with unipolar and bipolar depression. It remains unclear whether these changes are related to the clinical response. Future larger studies with longer follow-up are warranted to thoroughly address the potential role of CT as a biomarker of clinical response after ECT.

Indexed as

Bipolar DisorderBrain Cortical ThicknessCerebral CortexDepressive Disorder, Treatment-ResistantElectroconvulsive TherapyMajor Depressive DisorderHumansMagnetic Resonance ImagingTreatment Outcomecortical thicknessdepressionECTHamilton rating scale for depressiontreatment-resistant depression

Identifiers

PMID38343196
PMCPMC13130300
OpenAlexW4391749927

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.