ArticleThe clinical respiratory journal2024
Distinct age-adjusted D-dimer threshold to rule out acute pulmonary embolism in outpatients and inpatients.
Article in The clinical respiratory journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 5 citations in OpenAlex.
- Assessment of the modified glasgow prognostic scale and inflammatory parameters as a new prognostic indicator in pulmonary thromboembolism patients.BMC pulmonary medicine · 2026Article
- Differential analysis of coagulation indices (PT, APTT, d-dimer) in different types of thrombophilia.Medicine · 2025Observational
- A Comparative Analysis of the Impact of Severe Acute Respiratory Syndrome Coronavirus 2 Infection on the Performance of Clinical Decision-Making Algorithms for Pulmonary Embolism.Journal of clinical medicine · 2024Article
- Distinct age-adjusted D-dimer threshold to rule out acute pulmonary embolism in outpatients and inpatients.The clinical respiratory journal · 2024Article
- Correlation Between the Transient Increase of D-Dimer and Thrombolysis at 30d after Anticoagulation Therapy in Patients with Pulmonary Embolism.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisArticle
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5 authors at 3 institutions in 1 country.
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Abstract
introductionThe diagnosis of acute pulmonary embolism (PE) is combinations of clinical probability assessments, plasma D-dimer (DD) test results, and/or computed tomographic pulmonary angiography (CTPA).
objectiveThe aim of this study is to explore the appropriate DD cutoff using the immunoturbidimetric method in outpatients and inpatients.
methodsWe retrospectively enrolled 2689 patients with suspected PE between January 2014 and December 2019. All patients underwent clinical probability assessments, DD tests, and CTPA. We investigated the appropriate cutoff level for plasma DD tests in the correlation analysis and receiver operating characteristic (ROC) curves.
resultsAmong all patients, 1263 were confirmed acute PE. The age-adjusted DD level was determined to be age × 10 μg/L (for patients aged >50 years) in outpatients. This cutoff value resulted in a sensitivity of 96.75% and a specificity of 87.02%, with the area under the curve (AUC) of 0.908 and the number needed to treat (NNT) of 1.18. For inpatients, the age-adjusted cutoff values for the biomarker DD demonstrated poor specificity (13.34%) and NNT (9.88). However, when the DD cutoff was adjusted to 2 × the upper limit of normal (ULN), the sensitivity increased to 93.19%, while the specificity remained at 29.55%, with the AUC of 0.610 and the NNT of 4.76. The optimal DD cut-off value was 3010 μg/L (about 5 × ULN), resulting in a sensitivity of 75.22% and specificity of 61.72%, with the AUC of 0.727 and the NNT of 2.7.
conclusionUsing the immunoturbidimetric method to measure DD, an age-adjusted DD cutoff (age × 10 μg/L, if aged >50 years) should be considered for outpatients with suspected PE. For inpatients, increasing the DD cutoff value to at least 2 × ULN yields the best test performance.
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