Evidence map›Paper›PMID 38342811›Full record

ArticleBulletin of experimental biology and medicine2024

Effect of Gonadotropin-Releasing Hormone Antagonist on the Expression Patterns of Insulin-Like Growth Factor 1, Androgen Receptor, and Luteinizing Hormone Receptor in an Experimental Rat Model of Functional Ovarian Cysts.

O S Timofeeva, S V Logvinov, I A Petrov, O A Tikhonovskaya, Yu G Samoilova, Zh F Gaifulina, L R Mustafina, M S Petrova, A A Zhdankina, I G Kutsenko and 2 more

Abstract read
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In one paragraph

Article in Bulletin of experimental biology and medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

O S TimofeevaSiberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia. oksi91@bk.ru.
S V LogvinovSiberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia.
I A PetrovSiberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia.
O A TikhonovskayaSiberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia.
Yu G SamoilovaSiberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia.
Zh F GaifulinaSiberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia.
L R MustafinaSiberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia.
M S PetrovaSiberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia.
A A ZhdankinaSiberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia.
I G KutsenkoSiberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia.
D A KudlaySiberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia.
K A SidorenkovaSiberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia.
Ministry of Health of the Russian Federation · RUSiberian State Medical University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We studied the expression of insulin-like growth factor 1 (IGF-1), androgen receptor (AR) and luteinizing hormone receptor (LHR) in the ovaries under the conditions of the modeling and subsequent treatment of functional ovarian cysts with gonadotropin-releasing hormone antagonist (ant-GnRH). The intensity of IGF-1, LHR, and AR expression in the generative elements of rat ovaries changed under conditions of functional ovarian cysts simulation, as well as during treatment with ant-GnRH. In both experimental groups, the expression levels of the studied markers in preantral follicles and epithelial lining of cysts were found to be related to the number of growing follicles and cysts. A divergence of LHR and AR expression indices and a more pronounced decrease in the number of cystic cavities were observed in the group receiving ant-GnRH. These changes demonstrate a positive effect of ant-GnRH on intra-ovarian regulatory factors and a therapeutic effect in functional ovarian cysts.

Indexed as

CystsOvarian CystsAnimalsFemaleGonadotropin-Releasing HormoneHumansInsulin-Like Growth Factor IInsulin-Like PeptidesRatsReceptors, AndrogenReceptors, LHGonadotropin-Releasing HormoneInsulin-Like Growth Factor IInsulin-Like PeptidesReceptors, AndrogenReceptors, LHandrogen receptorfunctional ovarian cystsgonadotropin-releasing hormone antagonistinsulin-like growth factor 1luteinizing hormone receptor

Identifiers

PMID38342811
OpenAlexW4391750856

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.