Evidence map›Paper›PMID 38342617›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024

Self-Reinforced Bimetallic Mito-Jammer for Ca

Chier Du, Xun Guo, Xiaoling Qiu, Weixi Jiang, Xiaoting Wang, Hongjin An, Jingxue Wang, Yuanli Luo, Qianying Du, Ruoyao Wang and 8 more

Open access · goldAbstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
11.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 64 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 1 country.

Chier DuDepartment of Ultrasound and Chongqing Key Laboratory of Ultrasound Molecular Imaging, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, P. R. China.
Xun GuoDepartment of Ultrasound and Chongqing Key Laboratory of Ultrasound Molecular Imaging, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, P. R. China.
Xiaoling QiuDepartment of Intensive Care Unit, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, P. R. China.
Weixi JiangDepartment of Ultrasound and Chongqing Key Laboratory of Ultrasound Molecular Imaging, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, P. R. China.
Xiaoting WangDepartment of Ultrasound and Chongqing Key Laboratory of Ultrasound Molecular Imaging, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, P. R. China.
Hongjin AnDepartment of Ultrasound and Chongqing Key Laboratory of Ultrasound Molecular Imaging, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, P. R. China.
Jingxue WangDepartment of Ultrasound and Chongqing Key Laboratory of Ultrasound Molecular Imaging, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, P. R. China.
Yuanli LuoDepartment of Ultrasound and Chongqing Key Laboratory of Ultrasound Molecular Imaging, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, P. R. China.
Qianying DuDepartment of Radiology, Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, P. R. China.
Ruoyao WangDepartment of Breast and Thyroid Surgery, Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, P. R. China.
Chen ChengDepartment of Ultrasound and Chongqing Key Laboratory of Ultrasound Molecular Imaging, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, P. R. China.
Yuan GuoDepartment of Ultrasound and Chongqing Key Laboratory of Ultrasound Molecular Imaging, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, P. R. China.
Hua TengDepartment of Ultrasound and Chongqing Key Laboratory of Ultrasound Molecular Imaging, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, P. R. China.
Haitao RanDepartment of Ultrasound and Chongqing Key Laboratory of Ultrasound Molecular Imaging, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, P. R. China.
Zhigang WangDepartment of Ultrasound and Chongqing Key Laboratory of Ultrasound Molecular Imaging, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, P. R. China.
Pan LiDepartment of Ultrasound and Chongqing Key Laboratory of Ultrasound Molecular Imaging, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, P. R. China.
Zhiyi ZhouDepartment of General Practice, Chongqing General Hospital, Chongqing, 400010, P. R. China.
Jianli RenDepartment of Ultrasound and Chongqing Key Laboratory of Ultrasound Molecular Imaging, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, P. R. China.ORCID 0000-0003-1276-780X
Dalian Medical University · CNFirst People's Hospital of Chongqing · CN

Funding

Basic Research and Frontier Exploration Key Project of Chongqing Science and Technology Commission cstc2019jcyj-zdxmX0020Chongqing Science and Health Joint Medical Research Project-Young and Middle-Aged High-Level Project 2020GDRC011CQMU Program for Youth Innovation in Future Medicine W0026Kuanren Talents Program of the Second Affiliated Hospital of Chongqing Medical University KR2019G001National Natural Science Foundation of China 81873901National Natural Science Foundation of China 82102053National Natural Science Foundation of China 82171946National Natural Science Foundation of China 82272025Postdoctoral Science Foundation of China (Pre-Station) 2022TQ0396
6 · The paper itself

Abstract

Overproduction of reactive oxygen species (ROS), metal ion accumulation, and tricarboxylic acid cycle collapse are crucial factors in mitochondria-mediated cell death. However, the highly adaptive nature and damage-repair capabilities of malignant tumors strongly limit the efficacy of treatments based on a single treatment mode. To address this challenge, a self-reinforced bimetallic Mito-Jammer is developed by incorporating doxorubicin (DOX) and calcium peroxide (CaO

Indexed as

Hydrogen PeroxideNeoplasmsAdenosine TriphosphateCell DeathHumansMitomycinReactive Oxygen SpeciesTumor MicroenvironmentAdenosine TriphosphateHydrogen PeroxideMitomycinReactive Oxygen SpeciesCa2+ overloadcascade mitochondria damagechemodynamic therapycuproptosisimmunotherapy

Identifiers

PMID38342617
PMCPMC11022715
OpenAlexW4392730213

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.