Evidence map›Paper›PMID 38342608›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024

Pharmacological Polarization of Tumor-Associated Macrophages Toward a CXCL9 Antitumor Phenotype.

Noah Enbergs, Elias A Halabi, Anne-Gaëlle Goubet, Kelton Schleyer, Ina R Fredrich, Rainer H Kohler, Christopher S Garris, Mikaël J Pittet, Ralph Weissleder

Open access · goldAbstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 10 citations in OpenAlex.

  1. First-in-Human Study of the Carbohydrate NanoparticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Trial
  2. ZIF-8 nanoplatform coordinating ZnInternational journal of pharmaceutics: X · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Targeted SPP1 Inhibition of Tumor-Associated Myeloid Cells Effectively Decreases Tumor Sizes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Noah EnbergsCenter for Systems Biology, Massachusetts General Hospital, 185 Cambridge St, CPZN 5206, Boston, MA, 02114, USA.ORCID 0009-0009-9739-4723
Elias A HalabiCenter for Systems Biology, Massachusetts General Hospital, 185 Cambridge St, CPZN 5206, Boston, MA, 02114, USA.ORCID 0000-0003-1910-8196
Anne-Gaëlle GoubetDepartment of Pathology and Immunology, University of Geneva, Geneva, 1211, Switzerland.ORCID 0000-0003-3431-3067
Kelton SchleyerCenter for Systems Biology, Massachusetts General Hospital, 185 Cambridge St, CPZN 5206, Boston, MA, 02114, USA.ORCID 0000-0001-5385-8850
Ina R FredrichCenter for Systems Biology, Massachusetts General Hospital, 185 Cambridge St, CPZN 5206, Boston, MA, 02114, USA.ORCID 0000-0003-3242-1865
Rainer H KohlerCenter for Systems Biology, Massachusetts General Hospital, 185 Cambridge St, CPZN 5206, Boston, MA, 02114, USA.ORCID 0000-0001-6269-6590
Christopher S GarrisCenter for Systems Biology, Massachusetts General Hospital, 185 Cambridge St, CPZN 5206, Boston, MA, 02114, USA.ORCID 0000-0002-5764-6203
Mikaël J PittetDepartment of Pathology and Immunology, University of Geneva, Geneva, 1211, Switzerland.ORCID 0000-0002-2060-4691
Ralph WeisslederCenter for Systems Biology, Massachusetts General Hospital, 185 Cambridge St, CPZN 5206, Boston, MA, 02114, USA.ORCID 0000-0003-0828-4143
Massachusetts General Hospital · USUniversity of Geneva · CHHarvard University · US

Funding

Training Grant in Molecular Imaging Research (MGH/HMS)T32CA079443 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI WEISSLEDER, MD, PHD, RALPH · 2000 to 2025
$10.1M
Strategies to Overcome Immune Resistance in Head and Neck CancersP01CA240239 · NCI · YALE UNIVERSITY · PI MEMPEL, THORSTEN ROMAN · 2019 to 2023
$8.4M
Temporal analysis of the GBM tumor microenvironment during myeloid cell activating therapyR01CA281735 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI RALPH WEISSLEDER, MD, PhD · 2023 to 2026
$2.3M
NCI NIH HHS P01 CA240239NCI NIH HHS P01CA240239NCI NIH HHS R01 CA281735NCI NIH HHS R01CA281735NCI NIH HHS T32 CA079443NCI NIH HHS T32CA079443Swiss National Science Foundation P500PN_210730
6 · The paper itself

Abstract

Tumor-associated macrophages (TAM) are a diverse population of myeloid cells that are often abundant and immunosuppressive in human cancers. CXCL9

Indexed as

NeoplasmsTumor-Associated MacrophagesAnimalsChemokine CXCL9HumansMacrophagesMicePhenotypeChemokine CXCL9CXCL9 protein, humanCXCL9IFNgmacrophagenanoparticlesPARP7polarizationSTING

Identifiers

PMID38342608
PMCPMC11022742
OpenAlexW4392730216

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.