Evidence map›Paper›PMID 38342498›Full record

ArticleJournal of medical ethics2025

Ethical argument for establishing good manufacturing practice for phage therapy in the UK.

Mehrunisha Suleman, Jason R Clark, Susan Bull, Joshua D Jones

Abstract read
In one paragraph

Article in Journal of medical ethics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Review
  3. Bacteriophages targetingFrontiers in microbiology · 2026
    Review
  4. Review
  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mehrunisha SulemanEthox Center, Nuffield Department of Population Health, University of Oxford, Oxford, UK mehrunisha.suleman@ethox.ox.ac.uk.ORCID 0000-0002-8819-0659
Jason R ClarkKelvin Campus, Glasgow, UK.
Susan BullThe Ethox Centre, University of Oxford Medical Sciences Division, Oxford, UK.ORCID 0000-0002-9730-091X
Joshua D JonesClinical Microbiology, NHS Tayside, Dundee, UK.

Funding

Medical Research Council MC_PC_18046
6 · The paper itself

Abstract

Antimicrobial resistance (AMR) poses an increasing threat to patient care and population health and there is a growing need for novel therapies to tackle AMR. Bacteriophage (phage) therapy is a re-emerging antimicrobial strategy with the potential to transform how bacterial infections are treated in patients and populations. Currently, in the UK, phages can be used as unlicensed medicinal products on a 'named-patient' basis. We make an ethical case for why it is crucially important for the UK to invest in Good Manufacturing Practice (GMP) for both ongoing unlicensed and future licensed phage therapy. Access to phages produced to GMP (GMP phages) will ensure effective patient care and better outcomes as well as health systems benefits. The UK also has the potential to become a global leader in the timely and cost-efficient manufacturing and supply of a therapy that meets internationally recognised standards.

Indexed as

Bacterial InfectionsBacteriophagesPhage TherapyHumansUnited KingdomCommunicable DiseasesDecision MakingEthicsEthics- MedicalInternal Medicine

Identifiers

PMID38342498
PMCPMC12171505

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.