Evidence map›Paper›PMID 38342409›Full record

ArticleMolecular & cellular proteomics : MCP2024

Proximity Mapping of Desmosomes Reveals a Striking Shift in Their Molecular Neighborhood Associated With Maturation.

Judith B Fülle, Rogerio Alves de Almeida, Craig Lawless, Liam Stockdale, Bian Yanes, E Birgitte Lane, David R Garrod, Christoph Ballestrem

Open access · goldAbstract read
In one paragraph

Article in Molecular & cellular proteomics : MCP, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. The desmosome comes into focus.The Journal of cell biology · 2024
    Review
  5. Desmosomes at a glance.Journal of cell science · 2024
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Judith B FülleWellcome Trust Centre for Cell-Matrix Research, University of Manchester, Manchester, UK.
Rogerio Alves de AlmeidaWellcome Trust Centre for Cell-Matrix Research, University of Manchester, Manchester, UK.
Craig LawlessWellcome Trust Centre for Cell-Matrix Research, University of Manchester, Manchester, UK.
Liam StockdaleWellcome Trust Centre for Cell-Matrix Research, University of Manchester, Manchester, UK.
Bian YanesWellcome Trust Centre for Cell-Matrix Research, University of Manchester, Manchester, UK.
E Birgitte LaneSkin Research Institute of Singapore, Agency of Science Technology and Research (A∗STAR), Singapore, Singapore.
David R GarrodWellcome Trust Centre for Cell-Matrix Research, University of Manchester, Manchester, UK. Electronic address: david.garrod@manchester.ac.uk.
Christoph BallestremWellcome Trust Centre for Cell-Matrix Research, University of Manchester, Manchester, UK. Electronic address: christoph.ballestrem@manchester.ac.uk.
Wellcome Centre for Cell-Matrix Research · GBAgency for Science, Technology and Research · SG

Funding

BBSRC BB/R014361/1Biotechnology and Biological Sciences Research Council BB/R001707/1Wellcome TrustWellcome Trust 203128/Z/16/Z
6 · The paper itself

Abstract

Desmosomes are multiprotein adhesion complexes that link intermediate filaments to the plasma membrane, ensuring the mechanical integrity of cells across tissues, but how they participate in the wider signaling network to exert their full function is unclear. To investigate this, we carried out protein proximity mapping using biotinylation (BioID). The combined interactomes of the essential desmosomal proteins desmocollin 2a, plakoglobin, and plakophilin 2a (Pkp2a) in Madin-Darby canine kidney epithelial cells were mapped and their differences and commonalities characterized as desmosome matured from Ca

Indexed as

DesmosomesPlakophilinsAnimalsCell AdhesionCell MembraneDesmoplakinsDogsMadin Darby Canine Kidney CellsSignal TransductionDesmoplakinsPlakophilinsadhesion maturationBioIDcell-cell adhesiondesmocollindesmosomeepithelial cellshyper-adhesionintercellular junctionplakoglobinplakophilinproximitome

Identifiers

PMID38342409
PMCPMC10943070
OpenAlexW4391718673

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.