Evidence map›Paper›PMID 38342294›Full record

Observational studyResuscitation2024

The association between mechanical CPR and outcomes from in-hospital cardiac arrest: An observational cohort study.

Conor Crowley, Justin Salciccioli, Wei Wang, Tomoyoshi Tamura, Edy Y Kim, Ari Moskowitz, American Heart Association's Get With The Guidelines® – Resuscitation Investigators

Abstract readObservational StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Resuscitation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Observational
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Conor CrowleyDivision of Pulmonary and Critical Care Medicine, Lahey Hospital and Medical Center, Burlington, MA 01805, USA; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Tufts University School of Medicine, Boston, MA 02111, USA. Electronic address: conor.p.crowley@lahey.org.
Justin SalciccioliDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA.
Wei WangHarvard Medical School, Boston, MA 02115, USA; Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA 02115, USA.
Tomoyoshi TamuraDepartment of Emergency and Critical Care Medicine, Keio University School of Medicine, Tokyo, Japan.
Edy Y KimDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA.
Ari MoskowitzDivision of Critical Care Medicine, Montefiore Medical Center, the Bronx, New York, USA.
American Heart Association's Get With The Guidelines® – Resuscitation Investigators

Funding

RESPIRATORY RESEARCHT32HL007633 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI George R Washko · 1985 to 2026
$14.9M
Hospital Airway Resuscitation TrialR33HL162980 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI Ari Moskowitz · 2023 to 2026
$3.3M
Hospital Airway Resuscitation TrialR61HL162980 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI MOSKOWITZ, ARI · 2022 to 2022
$789k
NHLBI NIH HHS R33 HL162980NHLBI NIH HHS R61 HL162980NHLBI NIH HHS T32 HL007633
6 · The paper itself

Abstract

aimWe sought to investigate the relationship between mechanical cardiopulmonary resuscitation (CPR) during in-hospital cardiac arrest and survival to hospital discharge.

methodsUtilizing the prospectively collected American Heart Association's Get With The Guidelines database, we performed an observational study. Data from 153 institutions across the United States were reviewed with a total of 351,125 patients suffering cardiac arrest between 2011 and 2019 were screened. After excluding patients with cardiac arrests lasting less than 5 minutes, and patients who had incomplete data, a total of 111,143 patients were included. Our primary exposure was mechanical vs. manual CPR, and the primary outcome was survival to hospital discharge. Multivariate logistic regression models and propensity weighted analyses were used.

results11.8% of patients who received mechanical CPR survived to hospital discharge versus 16.9% in the manual CPR group. Patients who received mechanical CPR had a lower probability of survival to discharge compared to patients who received manual CPR (OR 0.66 95% CI 0.58-0.75; p < 0.001). This association persisted with multi-variable adjustment (OR 0.57 95% CI 0.46-0.70, p < 0.0001) and propensity weighted analysis (OR 0.68 95% CI 0.44-0 0.92, p < 0.0001). Mechanical CPR was associated with decrease likelihood of return of spontaneous circulation after multivariate adjustment (OR 0.68, 95% CI 0.60-0.76; p < 0.001).

conclusionsMechanical CPR was associated with a decreased likelihood of survival to hospital discharge and ROSC compared to manual CPR. This finding should be interpreted within the context of important limitations of this study and randomized trials are needed to better investigate this relationship.

Indexed as

Cardiopulmonary ResuscitationHeart ArrestAgedCohort StudiesFemaleHumansMaleMiddle AgedPatient DischargePropensity ScoreUnited StatesCardiopulmonary resuscitationHeart arrestIn-hospital cardiac arrestMechanical CPR

Identifiers

PMID38342294
PMCPMC11188584

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.