Evidence map›Paper›PMID 38341587›Full record

ArticleDiagnostic pathology2024

Killing capacity analysis of tumor-infiltrating cytotoxic lymphocytes and impact on lymph node metastasis in differentiated papillary carcinoma of thyroid with the BRAF V600E mutation.

Xiaogang Liu, Honggang Liu, Lu Wang, Yubing Han, Linghong Kong, Xinpeng Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diagnostic pathology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 98% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Xiaogang LiuDepartment of Pathology, Beijing Tongren Hospital, Beijing Key Laboratory of Head and Neck Molecular Diagnostic Pathology, Capital Medical University, Beijing, 100730, China.
Honggang LiuDepartment of Pathology, Beijing Tongren Hospital, Beijing Key Laboratory of Head and Neck Molecular Diagnostic Pathology, Capital Medical University, Beijing, 100730, China. liuhonggang@ccmu.edu.cn.
Lu WangDepartment of Pathology, Beijing Chuiyangliu Hospital, Beijing, 100022, China.
Yubing HanDepartment of Pathology, Beijing Chuiyangliu Hospital, Beijing, 100022, China.
Linghong KongDepartment of Pathology, Beijing Chuiyangliu Hospital, Beijing, 100022, China.
Xinpeng ZhangDepartment of Pathology, Beijing Chuiyangliu Hospital, Beijing, 100022, China.
Beijing Chuiyangliu Hospital · CNBeijing Tongren Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCytotoxic lymphocytes (CLs) express potent toxins, including perforin (P) and granzyme-B (G), which brings about target cell death. The purpose of this study was to evaluate the killing capacity of tumor-infiltrating CLs by means of P and G analysis, and explore the association with lymph node metastasis in papillary carcinoma of thyroid (PTC) without Hashimoto's thyroiditis (HT).

methodsInfiltration of lymphocytes in PTC was observed in frozen sections. Both fresh tumor tissues and paracancerous tissues with lymphocyte infiltration were collected and prepared into a single cell suspension. Flow cytometry was used to detect the percentages of CD3

resultsThe percentage of CD3

conclusionsThe killing capacity of infiltrating CLs in PTC differed between tumor tissues and paracancerous tissues. In cases with CCLNM, higher expression of CD16-CD56

Indexed as

Proto-Oncogene Proteins B-rafThyroid NeoplasmsHumansKiller Cells, NaturalLymphatic MetastasisMutationThyroid Cancer, PapillaryBRAF protein, humanProto-Oncogene Proteins B-rafCytotoxic lymphocytesGranzyme BLymph node metastasisPapillary carcinoma of the thyroidPerforin

Identifiers

PMID38341587
PMCPMC10858496
OpenAlexW4391723610

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.