ArticleScientific reports2024
Exploring the various effects of Cu doping in hydroxyapatite nanoparticle.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 46 citations in OpenAlex.
- Synthesis and Cytocompatibility of Bacterial Nanocellulose-Hydroxyapatite Biocomposites with Mg, Cu, Zn, and Sr Substitution.ACS omega · 2026Article
- Metal-Substituted Hydroxyapatite Nanoparticles as Antimicrobial and Osteogenic Biomaterials for Hard-Tissue Applications.Materials (Basel, Switzerland) · 2026Review
- Effect of NbInorganic chemistry · 2026Article
- UV photoluminescence and antimicrobial properties of silver ion modified calcined and non calcined eggshell based substrates.Discover nano · 2026Article
- Low Percent Copper Doping Limits Bacterial Adhesion on Fluorapatite-Based Bone Scaffolds.Journal of biomedical materials research. Part B, Applied biomaterials · 2026Article
- Synergistic effect of copper(ii) ions and orthosilicate group in nanosized hydroxyapatite.RSC advances · 2026Article
- Efficacy of Zinc-, Copper-, and Silver-Doped Fluorapatite as Bacteriophobic Surfaces for Percutaneous Osseointegrated Device Applications.ChemNanoMat : chemistry of nanomaterials for energy, biology and more · 2026Article
- Copper-doped β-tricalcium phosphate: synthesis, characterization, andMaterials today. Bio · 2026Article
- Synthesization of metal based-HAP catalysts for enhanced biodiesel yield from palm fatty acid distillate (PFAD).Scientific reports · 2026Article
- Ultrasound-Responsive Calcium Copper Phosphate Nanomaterials Induce Tumor Cell Death via the Synergistic Release of Copper and Calcium.International journal of molecular sciences · 2026Article
- Carnosine Biofunctionalized Hydroxyapatite Induces Copper-Driven Osteogenesis and Angiogenesis, Strengthening Its Bone Regenerative Capacities.ACS biomaterials science & engineering · 2025Article
- Chitosan-Hydrazone-Modified Calcium Phosphate Scaffolds: Fabrication, Characterization, and Drug Delivery Potential.Biomedicines · 2025Article
- Copper Impedes Calcification of Human Aortic Vascular Smooth Muscle Cells Through Inhibition of Osteogenic Transdifferentiation and Promotion of Extracellular Matrix Stability.Journal of cellular physiology · 2025Article
- In Situ Growth of Enamel-like Apatite Coating for Marble Protection.Materials (Basel, Switzerland) · 2025Article
- Article
- Visible Light-Sensitive Sustainable Quantum Dot Crystals of Co/Mg Doped Natural Hydroxyapatite Possessing Antimicrobial Activity and Biocompatibility.Small (Weinheim an der Bergstrasse, Germany) · 2024Article
- Enhanced antimicrobial efficacy of hydroxyapatite-based composites for healthcare applications.Scientific reports · 2024Article
- Physico-Chemical Properties of Copper-Doped Hydroxyapatite Coatings Obtained by Vacuum Deposition Technique.Materials (Basel, Switzerland) · 2024Article
- Copper metabolism in osteoarthritis and its relation to oxidative stress and ferroptosis in chondrocytes.Frontiers in molecular biosciences · 2024Review
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Adding foreign ions to hydroxyapatite (HAp) is a popular approach for improving its properties. This study focuses on the effects of calcium substitution with copper in HAp. Instead of calcium, copper ions were doped into the structure of hydroxyapatite nanoparticles at 1%, 3%, and 5% concentrations. XRD analysis showed that the amount of substituted copper was less than needed to generate a distinct phase, yet its lattice parameters and crystallinity slightly decreased. Further, the results of degradation tests revealed that copper doping in hydroxyapatite doubled calcium ion release in water. The incorporation of copper into the apatite structure also boosted the HAp zeta potential and FBS protein adsorption onto powders. According to antibacterial investigations, a concentration of 200 mg/ml of hydroxyapatite containing 5% copper was sufficient to effectively eradicate E. coli and S. aureus bacteria. Furthermore, copper improved hydroxyapatite biocompatibility. Alkaline phosphatase activity and alizarin red tests showed that copper in hydroxyapatite did not inhibit stem cell differentiation into osteoblasts. Also, the scratch test demonstrated that copper-containing hydroxyapatite extract increased HUVEC cell migration. Overall, our findings demonstrated the utility of incorporating copper into the structure of hydroxyapatite from several perspectives, including the induction of antibacterial characteristics, biocompatibility, and angiogenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.