Evidence map›Paper›PMID 38341403›Full record

ArticleNature communications2024

Mesoscopic calcium imaging in a head-unrestrained male non-human primate using a lensless microscope.

Jimin Wu, Yuzhi Chen, Ashok Veeraraghavan, Eyal Seidemann, Jacob T Robinson

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
11.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Primate neuroethology: a new synthesis.Trends in cognitive sciences · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Jimin Wu *Department of Bioengineering, Rice University, 6100 Main Street, Houston, TX, 77005, USA.ORCID 0000-0001-6383-9020
Yuzhi Chen *Department of Neuroscience, University of Texas at Austin, 100 E 24th St., Austin, TX, 78712, USA.
Ashok VeeraraghavanDepartment of Electrical and Computer Engineering, Rice University, 6100 Main Street, Houston, TX, 77005, USA.ORCID 0000-0001-5043-7460
Eyal SeidemannDepartment of Neuroscience, University of Texas at Austin, 100 E 24th St., Austin, TX, 78712, USA. eyal@austin.utexas.edu.ORCID 0000-0002-4873-3882
Jacob T RobinsonDepartment of Bioengineering, Rice University, 6100 Main Street, Houston, TX, 77005, USA. jtrobinson@rice.edu.ORCID 0000-0002-3509-3054
Rice University · USThe University of Texas at Austin · USBaylor College of Medicine · US

Funding

Resource Core 3 - Teaching/Training/Dissemination Core (TTDC)U19NS118284 · NINDS · STANFORD UNIVERSITY · PI GIOCOMO, LISA · 2021 to 2025
$18.1M
Linking Neural Population Activity and Visual PerceptionR01EY016454 · NEI · UNIVERSITY OF TEXAS AUSTIN · PI SEIDEMANN, EYAL J · 2005 to 2024
$6.6M
An optical-genetic toolbox for monitoring and controlling diverse neuromodulatory circuits governing complex behaviors in primatesUG3MH133047 · NIMH · UNIVERSITY OF TEXAS AT AUSTIN · PI DEISSEROTH, KARL A., SEIDEMANN, EYAL J · 2023 to 2025
$3.7M
Lensless, high-speed and multi-region volumetric Ca2+ imaging of up to 1cm2 brain surface across model animalsRF1NS110501 · NINDS · ROCKEFELLER UNIVERSITY · PI ROBINSON, JACOB T., VAZIRI, ALIPASHA · 2019 to 2019
$2.8M
National Science Foundation (NSF) IIS-1730574 and IIS-1652633NEI NIH HHS R01 EY016454NIMH NIH HHS UG3 MH133047NINDS NIH HHS RF1 NS110501NINDS NIH HHS U19 NS118284United States Department of Defense | Defense Advanced Research Projects Agency (DARPA) D20AC00002United States Department of Defense | Defense Advanced Research Projects Agency (DARPA) N66001-17-C-4012U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01EY016454 and U19NS118284U.S. Department of Health & Human Services | National Institutes of Health (NIH) RF1NS110501
6 · The paper itself

Abstract

Mesoscopic calcium imaging enables studies of cell-type specific neural activity over large areas. A growing body of literature suggests that neural activity can be different when animals are free to move compared to when they are restrained. Unfortunately, existing systems for imaging calcium dynamics over large areas in non-human primates (NHPs) are table-top devices that require restraint of the animal's head. Here, we demonstrate an imaging device capable of imaging mesoscale calcium activity in a head-unrestrained male non-human primate. We successfully miniaturize our system by replacing lenses with an optical mask and computational algorithms. The resulting lensless microscope can fit comfortably on an NHP, allowing its head to move freely while imaging. We are able to measure orientation columns maps over a 20 mm

Indexed as

CalciumMicroscopyAnimalsMalePrimatesCalcium

Identifiers

PMID38341403
PMCPMC10858944
OpenAlexW4391723603

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.