Evidence map›Paper›PMID 38341283›Full record

Trial reportBritish journal of anaesthesia2024

Preoperative N-terminal pro-B-type natriuretic peptide and myocardial injury after stopping or continuing renin-angiotensin system inhibitors in noncardiac surgery: a prespecified analysis of a phase 2 randomised controlled multicentre trial.

Ana Gutierrez Del Arroyo, Akshaykumar Patel, Tom E F Abbott, Salma Begum, Priyanthi Dias, Sameer Somanath, Alexander Middleditch, Stuart Cleland, David Brealey, Rupert M Pearse and 2 more

Open access · hybridAbstract readRandomized Controlled TrialMulticenter StudyClinical Trial, Phase II
PubMed Full text at PMC Publisher
In one paragraph

Trial report in British journal of anaesthesia, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Ana Gutierrez Del ArroyoTranslational Medicine and Therapeutics, William Harvey Research Institute, Queen Mary University of London, London, UK.
Akshaykumar PatelTranslational Medicine and Therapeutics, William Harvey Research Institute, Queen Mary University of London, London, UK.
Tom E F AbbottTranslational Medicine and Therapeutics, William Harvey Research Institute, Queen Mary University of London, London, UK.
Salma BegumTranslational Medicine and Therapeutics, William Harvey Research Institute, Queen Mary University of London, London, UK.
Priyanthi DiasTranslational Medicine and Therapeutics, William Harvey Research Institute, Queen Mary University of London, London, UK.
Sameer SomanathCounty Durham and Darlington NHS Foundation Trust, Durham, UK.
Alexander MiddleditchUniversity Hospitals Bristol NHS Foundation Trust, Bristol, UK.
Stuart ClelandUniversity Hospitals Plymouth NHS Trust, Plymouth, UK.
David BrealeyBloomsbury Institute of Intensive Care Medicine, University College London, London, UK; UCL Hospitals NHS Foundation Trust, London, UK.
Rupert M PearseTranslational Medicine and Therapeutics, William Harvey Research Institute, Queen Mary University of London, London, UK.
Gareth L AcklandTranslational Medicine and Therapeutics, William Harvey Research Institute, Queen Mary University of London, London, UK. Electronic address: g.ackland@qmul.ac.uk.
SPACE trial investigators
Queen Mary University of London · GBCounty Durham and Darlington NHS Foundation Trust · GBUniversity College London Hospitals NHS Foundation Trust · GBUniversity Hospitals Bristol NHS Foundation Trust · GBUniversity Hospitals Plymouth NHS Trust · GB

Funding

British Heart Foundation RG/19/5/34463
6 · The paper itself

Abstract

backgroundPatients with elevated preoperative plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP >100 pg ml

methodsIn a preplanned analysis of a phase 2a trial in six UK centres, patients ≥60 yr old undergoing elective noncardiac surgery were randomly assigned either to stop or continue RAS inhibitors before surgery. The pharmacokinetic profile of individual RAS inhibitors determined for how long they were stopped before surgery. The primary outcome, masked to investigators, clinicians, and patients, was myocardial injury (plasma high-sensitivity troponin-T ≥15 ng L

resultsOf 241 participants, 101 (41.9%; mean age 71 [7] yr; 48% females) had preoperative NT-proBNP >100 pg ml

conclusionsStopping renin-angiotensin system inhibitors in lower-risk patients (preoperative NT-proBNP <100 pg ml

Indexed as

Heart InjuriesNatriuretic Peptide, BrainAgedBiomarkersFemaleHumansMalePeptide FragmentsRenin-Angiotensin SystemTroponin TBiomarkersNatriuretic Peptide, BrainPeptide Fragmentspro-brain natriuretic peptide (1-76)Troponin Tmajor cardiac eventsmyocardial injurynoncardiac surgeryperioperative carerenin-angiotensin system inhibitors

Identifiers

PMID38341283
PMCPMC11103084
OpenAlexW4391676740

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.