Evidence map›Paper›PMID 38340967›Full record

ArticleMatrix biology : journal of the International Society for Matrix Biology2024

Dysfunctional latent transforming growth factor β activation after corneal injury in a classical Ehlers-Danlos model.

Mei Sun, Ana Carolina Acosta, Victoria Emerick, Sheila Adams, Marcel Y Avila, Curtis E Margo, Edgar M Espana

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Matrix biology : journal of the International Society for Matrix Biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Mei SunDepartment of Ophthalmology, Cornea and External Disease, Morsani College of Medicine, University of South Florida, 13330 USF Laurel Dr., 4th floor, MDC11, Tampa, FL 33612, USA.
Ana Carolina AcostaDepartment of Ophthalmology, Cornea and External Disease, Morsani College of Medicine, University of South Florida, 13330 USF Laurel Dr., 4th floor, MDC11, Tampa, FL 33612, USA.
Victoria EmerickDepartment of Ophthalmology, Cornea and External Disease, Morsani College of Medicine, University of South Florida, 13330 USF Laurel Dr., 4th floor, MDC11, Tampa, FL 33612, USA.
Sheila AdamsDepartment of Ophthalmology, Cornea and External Disease, Morsani College of Medicine, University of South Florida, 13330 USF Laurel Dr., 4th floor, MDC11, Tampa, FL 33612, USA.
Marcel Y AvilaDepartament of Ophthalmology, Universidad Nacional de Colombia, Bogota, Colombia.
Curtis E MargoDepartment of Ophthalmology, Cornea and External Disease, Morsani College of Medicine, University of South Florida, 13330 USF Laurel Dr., 4th floor, MDC11, Tampa, FL 33612, USA; Pathology and Cell Biology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Edgar M EspanaDepartment of Ophthalmology, Cornea and External Disease, Morsani College of Medicine, University of South Florida, 13330 USF Laurel Dr., 4th floor, MDC11, Tampa, FL 33612, USA; Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA. Electronic address: eespana@usf.edu.
University of South Florida · USUniversidad Nacional de Colombia · CO

Funding

Regulation of tissue repair and scar formation by the stromal nicheR01EY034114 · NEI · UNIVERSITY OF SOUTH FLORIDA · PI Edgar Mauricio Espana · 2022 to 2026
$2.1M
Regulatory roles for collagen XII in establishment of corneal stromal structure and function and re-establishment after injuryR01EY029395 · NEI · UNIVERSITY OF SOUTH FLORIDA · PI ESPANA, EDGAR MAURICIO · 2018 to 2022
$1.8M
NEI NIH HHS R01 EY029395NEI NIH HHS R01 EY034114
6 · The paper itself

Abstract

Patients with classical Ehlers Danlos syndrome (cEDS) suffer impaired wound healing and from scars formed after injuries that are atrophic and difficult to close surgically. Haploinsufficiency in COL5A1 creates systemic morphological and functional alterations in the entire body. We investigated mechanisms that impair wound healing from corneal lacerations (full thickness injuries) in a mouse model of cEDS (Col5a1

Indexed as

Corneal InjuriesEhlers-Danlos SyndromeSkin AbnormalitiesAnimalsCicatrixCollagenHumansMiceTransforming Growth Factor betaCollagenTransforming Growth Factor betaCollagensFibroblastsStromaWound

Identifiers

PMID38340967
PMCPMC10996040
OpenAlexW4391690923

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.