Evidence map›Paper›PMID 38340195›Full record

ArticleBulletin of experimental biology and medicine2024

Effect of Inducers and Inhibitors of the Keap1/Nrf2/ARE System on the Viability and Functional Activity of Model Neuronal-Like and Glial Cells.

E B Menshchikova, A V Chechushkov, P M Kozhin, L P Romakh, A E Serykh, M V Khrapova, E S Petrova, N V Kandalintseva

Abstract read
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In one paragraph

Article in Bulletin of experimental biology and medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

E B MenshchikovaFederal Research Center for Fundamental and Translational Medicine, Novosibirsk, Russia. lemen@centercem.ru.
A V ChechushkovFederal Research Center for Fundamental and Translational Medicine, Novosibirsk, Russia.
P M KozhinFederal Research Center for Fundamental and Translational Medicine, Novosibirsk, Russia.
L P RomakhFederal Research Center for Fundamental and Translational Medicine, Novosibirsk, Russia.
A E SerykhFederal Research Center for Fundamental and Translational Medicine, Novosibirsk, Russia.
M V KhrapovaFederal Research Center for Fundamental and Translational Medicine, Novosibirsk, Russia.
E S PetrovaFederal Research Center for Fundamental and Translational Medicine, Novosibirsk, Russia.
N V KandalintsevaNovosibirsk State Pedagogical University, Novosibirsk, Russia.
Federal Research Center of Fundamental and Translational Medicine · RUNovosibirsk State Pedagogical University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

On mouse neuroblastoma (Neuro-2a) and human glioblastoma (U-87 MG) cell lines, we studied the effect of inducers and inhibitors of redox-sensitive signaling system of the antioxidant-responsive element Keap1/Nrf2/ARE on the main processes that determine nerve cell viability and vital activity (proliferative activity, apoptosis, autophagy, and activation of the Keap1/Nrf2/ARE system). Inhibitors of the Keap1/Nrf2/ARE system stimulate apoptosis more pronouncedly than inducers, have a weaker effect on autophagy, and do not change the nuclear to cytoplasmic Nrf2 ratio. In general, the revealed effects testify in favor of the potential effectiveness of stimulating the Keap1/Nrf2/ARE system for the prevention and adjuvant therapy of neurodegenerative diseases.

Indexed as

NF-E2-Related Factor 2Signal TransductionAnimalsAntioxidantsHumansKelch-Like ECH-Associated Protein 1MiceNeurogliaOxidative StressAntioxidantsKeap1 protein, mouseKelch-Like ECH-Associated Protein 1NF-E2-Related Factor 2apoptosisautophagyKeap1/Nrf2/ARE systemneurodegenerative diseasesproliferation

Identifiers

PMID38340195
OpenAlexW4391718524

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.