Evidence map›Paper›PMID 38340081›Full record

ArticleThe Journal of physiology2025

Inhibition and potentiation of the exercise pressor reflex by pharmacological modulation of TRPC6 in male rats.

Guillaume P Ducrocq, Laura Anselmi, Salvatore L Stella, Steven W Copp, Victor Ruiz-Velasco, Marc P Kaufman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Guillaume P DucrocqHeart and Vascular Institute, Penn State College of Medicine, Hershey, PA, USA.ORCID 0000-0003-3531-4678
Laura AnselmiHeart and Vascular Institute, Penn State College of Medicine, Hershey, PA, USA.ORCID 0000-0001-8558-1155
Salvatore L StellaDepartment of Neurobiology and Behavioral Sciences, Penn State College of Medicine, Hershey, PA, USA.
Steven W CoppDepartment of Kinesiology, Kansas State University, Manhattan, KS, USA.
Victor Ruiz-VelascoHeart and Vascular Institute, Penn State College of Medicine, Hershey, PA, USA.
Marc P KaufmanHeart and Vascular Institute, Penn State College of Medicine, Hershey, PA, USA.

Funding

Opioid-induced potentiation of the exercise pressor reflex via acid-sensing ion channels (ASIC3) in health and simulated peripheral artery diseaseR01HL156513 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI RUIZ-VELASCO, VICTOR · 2021 to 2024
$2.4M
Role played by Acid Ion Sensing Channels in Peripheral Artery DiseaseR01HL156594 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI KAUFMAN, MARC PETER, RUIZ-VELASCO, VICTOR · 2021 to 2024
$2.3M
Signaling pathways regulating mechanoreflex sensitization in cardiovascular diseaseR01HL161160 · NHLBI · KANSAS STATE UNIVERSITY · PI COPP, STEVEN W · 2022 to 2025
$2.1M
NHLBI NIH HHS R01 HL156513NHLBI NIH HHS R01 HL156594NHLBI NIH HHS R01 HL161160
6 · The paper itself

Abstract

We determined the role played by the transient receptor potential canonical 6 (TRPC6) channel in evoking the mechanical component of the exercise pressor reflex in male decerebrated Sprague-Dawley rats. TRPC6 channels were identified by quadruple-labelled (DiI, TRPC6, neurofilament-200 and peripherin) immunohistochemistry in dorsal root ganglion (DRG) cells innervating the triceps surae muscles (n = 12). The exercise pressor reflex was evoked by statically contracting the triceps surae muscles before and after injection of the TRPC6 antagonist BI-749327 (n = 11; 12 μg kg

Indexed as

Physical Conditioning, AnimalReflexTRPC Cation ChannelsAnimalsBlood PressureGanglia, SpinalKidneyMaleMuscle ContractionMuscle, SkeletalRatsRats, Sprague-DawleySympathetic Nervous SystemTRPC6 Cation ChannelTRPC6 Cation ChannelTrpc6 protein, ratTRPC Cation Channelsexercise pressor refleximmunohistochemistrymechanoreflexneural control of autonomic circulationsympathetic nervous systemtransient receptor potential canonical 6

Identifiers

PMID38340081
PMCPMC11315811

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.