Evidence map›Paper›PMID 38339996›Full record

SynthesisJournal of the Pediatric Infectious Diseases Society2024

Guidance for prevention and management of COVID-19 in children and adolescents: A consensus statement from the Pediatric Infectious Diseases Society Pediatric COVID-19 Therapies Taskforce.

Zachary I Willis, Carlos R Oliveira, Mark J Abzug, Brenda I Anosike, Monica I Ardura, Laura L Bio, Juri Boguniewicz, Kathleen Chiotos, Kevin Downes, Steven P Grapentine and 22 more

Open access · bronzeAbstract readSystematic ReviewMeta-AnalysisConsensus Statement
In one paragraph

Synthesis in Journal of the Pediatric Infectious Diseases Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors at 20 institutions in 1 country.

Zachary I WillisDepartment of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NC, USA.ORCID 0000-0002-6372-5274
Carlos R OliveiraDepartment of Pediatrics, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0003-1897-6581
Mark J AbzugDepartment of Pediatrics, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO, USA.
Brenda I AnosikeDepartment of Pediatrics, The Children's Hospital at Montefiore and Albert Einstein College of Medicine, Bronx, NY, USA.
Monica I ArduraDepartment of Pediatrics, ID Host Defense Program, Nationwide Children's Hospital & The Ohio State University, Columbus, OH, USA.ORCID 0000-0002-2853-2581
Laura L BioDepartment of Pharmacy, Lucile Packard Children's Hospital, Stanford, CA, USA.ORCID 0000-0001-9520-6420
Juri BoguniewiczDepartment of Pediatrics, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO, USA.ORCID 0000-0002-9248-780X
Kathleen ChiotosDepartments of Anesthesiology, Critical Care Medicine, and Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Divisions of Critical Care Medicine and Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Kevin DownesDepartment of Pediatrics, Perelman School of Medicine of the University of Pennsylvania, Division of Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0000-0001-5015-8146
Steven P GrapentineDepartment of Pharmacy, University of California San Francisco Benioff Children's Hospital, San Francisco, CA, USA.
Adam L HershDepartment of Pediatrics, Division of Infectious Diseases, University of Utah, Salt Lake City, UT, USA.
Sarah M HestonDepartment of Pediatrics, Duke University School of Medicine, Durham, NC, USA.ORCID 0000-0001-6150-1149
Diego R HijanoDepartment of Infectious Diseases, St. Jude Children's Research Hospital and Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN, USA.ORCID 0000-0002-2903-666X
W Charles HuskinsDepartment of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.
Scott H JamesDepartment of Pediatrics, Division of Pediatric Infectious Diseases, University of Alabama at Birmingham, Birmingham, AL, USA.
Sarah JonesDepartment of Pharmacy, Boston Children's Hospital, Boston, MA, USA.
Christine R LockowitzDepartment of Pharmacy, St. Louis Children's Hospital, St. Louis, Missouri, USA.
Elizabeth C LloydDepartment of Pediatrics, University of Michigan, Ann Arbor, MI, USA.
Christine MacBrayneDepartment of Pharmacy, Children's Hospital Colorado, Aurora, CO, USA.
Gabriela M MaronDepartment of Infectious Diseases, St. Jude Children's Research Hospital and Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN, USA.
Molly Hayes McDonoughCenter for Healthcare Quality & Analytics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0000-0003-3270-6633
Christine M MillerDepartment of Pediatrics, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0003-0486-5047
Theodore H MortonDepartment of Pharmacy, St Jude's Children's Research Hospital, Memphis, Tennessee, USA.
Rosemary M OliveroDepartment of Pediatrics and Human Development, Michigan State College of Human Medicine and Helen DeVos Children's Hospital of Corewell Health, Grand Rapids, MI, USA.
Rachel C OrschelnDepartment of Pediatrics, Washington University, St. Louis, MO, USA.
Hayden T SchwenkDepartment of Pediatrics, Stanford School of Medicine, Stanford, CA, USA.ORCID 0000-0002-8164-8655
Prachi SinghDepartment of Pediatrics, University of California San Francisco, San Francisco, CA, USA.
Vijaya L SomaDepartment of Pediatrics, NYU Grossman School of Medicine, New York, NY, USA.
Paul K SueDepartment of Pediatrics, Columbia University, New York, NY, USA.
Surabhi B VoraDepartment of Pediatrics, University of Washington School of Medicine, and Division of Infectious Diseases, Seattle Children's Hospital, Seattle, WA, USA.
Mari M NakamuraAntimicrobial Stewardship Program and Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0002-8191-0027
Joshua WolfDepartment of Infectious Diseases, St. Jude Children's Research Hospital and Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN, USA.ORCID 0000-0002-9912-3646
St. Jude Children's Research Hospital · USChildren's Hospital Colorado · USChildren's Hospital of Philadelphia · USBoston Children's Hospital · USUniversity of California, San Francisco · USYale University · USAlbert Einstein College of Medicine · USColumbia University · USDuke University · USHelen DeVos Children's Hospital · USLucile Packard Children's Hospital · USMayo Clinic in Florida · USNationwide Children's Hospital · USNew York University · USSeattle Children's Hospital · USStanford Medicine · USSt. Louis Children's Hospital · USUniversity of Alabama at Birmingham · USUniversity of Michigan · USUniversity of North Carolina at Chapel Hill · US

Funding

NRSA Training CoreTL1TR001864 · NCATS · YALE UNIVERSITY · PI CANTLEY, LLOYD G, EDELMAN, E. JENNIFER · 2016 to 2025
$9.9M
Clinical Epidemiology of Pediatric COVID-19 and MIS-CK23AI159518 · NIAID · YALE UNIVERSITY · PI OLIVEIRA, CARLOS RAFAEL · 2021 to 2024
$729k
NCATS NIH HHS TL1 TR001864NIAID NIH HHS K23 AI159518
6 · The paper itself

Abstract

backgroundSince November 2019, the SARS-CoV-2 pandemic has created challenges for preventing and managing COVID-19 in children and adolescents. Most research to develop new therapeutic interventions or to repurpose existing ones has been undertaken in adults, and although most cases of infection in pediatric populations are mild, there have been many cases of critical and fatal infection. Understanding the risk factors for severe illness and the evidence for safety, efficacy, and effectiveness of therapies for COVID-19 in children is necessary to optimize therapy.

methodsA panel of experts in pediatric infectious diseases, pediatric infectious diseases pharmacology, and pediatric intensive care medicine from 21 geographically diverse North American institutions was re-convened. Through a series of teleconferences and web-based surveys and a systematic review with meta-analysis of data for risk factors, a guidance statement comprising a series of recommendations for risk stratification, treatment, and prevention of COVID-19 was developed and refined based on expert consensus.

resultsThere are identifiable clinical characteristics that enable risk stratification for patients at risk for severe COVID-19. These risk factors can be used to guide the treatment of hospitalized and non-hospitalized children and adolescents with COVID-19 and to guide preventative therapy where options remain available.

Indexed as

COVID-19COVID-19 Drug TreatmentSARS-CoV-2AdolescentAntiviral AgentsChildHumansRisk FactorsAntiviral AgentsCOVID-19evidence-basedguidancemanagementpediatric

Identifiers

PMID38339996
PMCPMC11494238
OpenAlexW4391719013

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.