ArticleHuman brain mapping2024
Age-related positive emotional reactivity decline associated with the anterior insula based resting-state functional connectivity.
Article in Human brain mapping, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 6 citations in OpenAlex.
- Functional brain abnormalities in patients with somatic symptom disorder presenting with chest pain: a resting-state fMRI study.Scientific reports · 2026Article
- The Desegregation of Neural Networks During Worry Induction in Late Life: An Effective Connectivity Analysis.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Age-related positive emotional reactivity decline associated with the anterior insula based resting-state functional connectivity.Human brain mapping · 2024Article
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Recent studies have suggested that emotional reactivity changes with age, but the neural basis is still unclear. The insula may be critical for the emotional reactivity. The current study examined how ageing affects emotional reactivity using the emotional reactivity task data from a human sample (Cambridge Center for Age and Neuroscience, N = 243, age 18-88 years). The resting-state magnetic resonance measurements from the same sample were used to investigate the potential mechanisms of the insula. In the initial analysis, we conducted partial correlation assessments to examine the associations between emotional reactivity and age, as well as between the gray matter volume (GMV) of the insula and age. Our results revealed that emotional reactivity, especially positive emotional reactivity, decreased with age and that the GMV of the insula was negatively correlated with age. Subsequently, the bilateral insula was divided into six subregions to calculate the whole brain resting-state functional connectivity (rsFC). The mediating effect of the rsFC on age and emotional reactivity was then calculated. The results showed that the rsFC of the left anterior insula (AI) with the right hippocampus, and the rsFCs of the right AI with the striatum and the thalamus were mediated the relationship between positive emotional reactivity and age. Our findings suggest that attenuating emotional reactivity with age may be a strategic adaptation fostering emotional stability and diminishing emotional vulnerability. Meanwhile, the findings implicate a key role for the AI in the changes in positive emotional reactivity with age.
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Registered trials
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