Evidence map›Paper›PMID 38339386›Full record

ArticleCancers2024

Survival of Women with Advanced Stage Cervical Cancer: Neo-Adjuvant Chemotherapy Followed by Radiotherapy and Hyperthermia versus Chemoradiotherapy.

Jonathan Servayge, Ester P Olthof, Constantijne H Mom, Maaike A van der Aa, Hans H B Wenzel, Jacobus van der Velden, Remi A Nout, Ingrid A Boere, Helena C van Doorn, Heleen J van Beekhuizen

Abstract read
In one paragraph

Article in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Molecular medicine reports · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jonathan ServaygeDepartment of Gynecologic Oncology, Erasmus MC Cancer Institute, University Medical Centre Rotterdam, 3000 CA Rotterdam, The Netherlands.
Ester P OlthofDepartment of Gynecologic Oncology, Amsterdam University Medical Centre, Centre for Gynecologic Oncology Amsterdam (CGOA), 1066 CX Amsterdam, The Netherlands.ORCID 0000-0003-1941-7693
Constantijne H MomDepartment of Gynecologic Oncology, Amsterdam University Medical Centre, Centre for Gynecologic Oncology Amsterdam (CGOA), 1066 CX Amsterdam, The Netherlands.
Maaike A van der AaDepartment of Research and Development, Netherlands Comprehensive Cancer Organisation (IKNL), 3501 DB Utrecht, The Netherlands.
Hans H B WenzelDepartment of Research and Development, Netherlands Comprehensive Cancer Organisation (IKNL), 3501 DB Utrecht, The Netherlands.
Jacobus van der VeldenDepartment of Gynecologic Oncology, Amsterdam University Medical Centre, Centre for Gynecologic Oncology Amsterdam (CGOA), 1066 CX Amsterdam, The Netherlands.ORCID 0000-0002-5985-1163
Remi A NoutDepartment of Radiotherapy, Erasmus MC Cancer Institute, University Medical Centre Rotterdam, 3000 CA Rotterdam, The Netherlands.
Ingrid A BoereDepartment of Medical Oncology, Erasmus MC Cancer Institute, University Medical Centre Rotterdam, 3000 CA Rotterdam, The Netherlands.ORCID 0000-0002-4857-6346
Helena C van DoornDepartment of Gynecologic Oncology, Erasmus MC Cancer Institute, University Medical Centre Rotterdam, 3000 CA Rotterdam, The Netherlands.ORCID 0000-0003-1062-4485
Heleen J van BeekhuizenDepartment of Gynecologic Oncology, Erasmus MC Cancer Institute, University Medical Centre Rotterdam, 3000 CA Rotterdam, The Netherlands.ORCID 0000-0001-8899-7412

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo investigate and compare overall survival (OS), disease-free survival (DFS) and toxicity of women who underwent either chemoradiotherapy with or without prior lymph node debulking or upfront chemotherapy followed by radiotherapy and hyperthermia (triple therapy) for locally advanced cervical cancer (LACC) to identify a potential role for triple therapy.

methodsWomen with histologically proven LACC and with International Federation of Gynecology and Obstetrics (FIGO) 2009 stage IB2 and IIA2 to IVA were included. Cox regression analyses were used for calculating hazard ratios and to adjust for confounding variables. A multivariable logistic regression analysis was used to examine the influence of covariates on toxicity.

resultsA total of 370 patients were included of whom 58% (

conclusionThis study suggests that the toxicity and survival of TT is similar to CRT or LND-CRT.

Indexed as

chemoradiotherapydisease-free survivalhyperthermialocally advanced cervical cancerlymph node debulkingoverall survivaltoxicity

Identifiers

PMID38339386
PMCPMC10854526

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.