Evidence map›Paper›PMID 38339373›Full record

ArticleCancers2024

A Validated Methodological Approach to Prove the Safety of Clinical Electromagnetic Induction Systems in Magnetic Hyperthermia.

Maria Anastasia Rouni, Boaz Shalev, George Tsanidis, Ioannis Markakis, Sarah Kraus, Pazit Rukenstein, Doron Suchi, Ofer Shalev, Theodoros Samaras

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Design, verification and validation of a spatially confined magnetic nanoparticle thermal therapy device for conformal thermal dose contouring.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2026
    Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Advances in magnetic induction hyperthermia.Frontiers in bioengineering and biotechnology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Maria Anastasia RouniThessaloniki Software Solutions S.A., 55535 Thessaloniki, Greece.ORCID 0000-0003-2752-9935
Boaz ShalevNew Phase Ltd., Petah Tikva 4934829, Israel.ORCID 0009-0004-7070-9821
George TsanidisThessaloniki Software Solutions S.A., 55535 Thessaloniki, Greece.ORCID 0000-0002-6099-2174
Ioannis MarkakisThessaloniki Software Solutions S.A., 55535 Thessaloniki, Greece.ORCID 0000-0002-7420-997X
Sarah KrausNew Phase Ltd., Petah Tikva 4934829, Israel.ORCID 0000-0003-1083-0297
Pazit RukensteinNew Phase Ltd., Petah Tikva 4934829, Israel.
Doron SuchiNew Phase Ltd., Petah Tikva 4934829, Israel.
Ofer ShalevNew Phase Ltd., Petah Tikva 4934829, Israel.
Theodoros SamarasFaculty of Sciences, School of Physics, Aristotle University, 54124 Thessaloniki, Greece.ORCID 0000-0003-0170-4520
Aristotle University of Thessaloniki · GRUniversity of Malta · MT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present study focuses on the development of a methodology for evaluating the safety of MNH systems, through the numerical prediction of the induced temperature rise in superficial skin layers due to eddy currents heating under an alternating magnetic field (AMF). The methodology is supported and validated through experimental measurements of the AMF's distribution, as well as temperature data from the torsos of six patients who participated in a clinical trial study. The simulations involved a computational model of the actual coil, a computational model of the cooling system used for the cooling of the patients during treatment, and a detailed human anatomical model from the Virtual Population family. The numerical predictions exhibit strong agreement with the experimental measurements, and the deviations are below the estimated combined uncertainties, confirming the accuracy of computational modeling. This study highlights the crucial role of simulations for translational medicine and paves the way for personalized treatment planning.

Indexed as

anatomical human modelmagnetic nanoparticle hyperthermiaPennes BioHeat equationSim4Lifetemperature-dependent perfusion

Identifiers

PMID38339373
PMCPMC10854696
OpenAlexW4391404236

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.