Evidence map›Paper›PMID 38339290›Full record

ReviewCancers2024

Optimizing Clinical Implementation of Hypofractionation: Comprehensive Evidence Synthesis and Practical Guidelines for Low- and Middle-Income Settings.

Maria Thereza Mansur Starling, Stephane Thibodeau, Cecília Félix Penido Mendes de Sousa, Felipe Cicci Farinha Restini, Gustavo A Viani, Andre G Gouveia, Lucas C Mendez, Gustavo Nader Marta, Fabio Ynoe Moraes

Abstract readReview
In one paragraph

Review in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Efficacy and safety of hypofractionated radiotherapy versus conventional fractionated radiotherapy in diffuse intrinsic pontine glioma: A systematic review and meta-analysis.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2024
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Maria Thereza Mansur StarlingDivision of Radiation Oncology, Department of Oncology, London Health Sciences Centre, London, ON N6A 5W9, Canada.
Stephane ThibodeauDivision of Radiation Oncology, Department of Oncology, Kingston General Hospital, Queen's University, Kingston, ON K7L 3N6, Canada.
Cecília Félix Penido Mendes de SousaJohns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Felipe Cicci Farinha RestiniRadiation Oncology Department, Hospital Sirio Libanês, Sao Paulo 01308-050, Brazil.
Gustavo A VianiDepartment of Medical Imagings, Ribeirão Preto Medical School, Hematology and Oncology of University of São Paulo (FMRP-USP), Ribeirão Preto 14049-900, Brazil.
Andre G GouveiaLatin America Cooperative Oncology Group (LACOG), Porto Alegre 90619-900, Brazil.ORCID 0000-0001-7055-3557
Lucas C MendezDivision of Radiation Oncology, Department of Oncology, London Health Sciences Centre, London, ON N6A 5W9, Canada.
Gustavo Nader MartaRadiation Oncology Department, Hospital Sirio Libanês, Sao Paulo 01308-050, Brazil.ORCID 0000-0002-3298-3684
Fabio Ynoe MoraesDivision of Radiation Oncology, Department of Oncology, Kingston General Hospital, Queen's University, Kingston, ON K7L 3N6, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The global cancer burden, especially in low- and middle-income countries (LMICs), worsens existing disparities, amplified by the rising costs of advanced treatments. The shortage of radiation therapy (RT) services is a significant issue in LMICs. Extended conventional treatment regimens pose significant challenges, especially in resource-limited settings. Hypofractionated radiotherapy (HRT) and ultra-hypofractionated/stereotactic body radiation therapy (SBRT) offer promising alternatives by shortening treatment durations. This approach optimizes the utilization of radiotherapy machines, making them more effective in meeting the growing demand for cancer care. Adopting HRT/SBRT holds significant potential, especially in LMICs. This review provides the latest clinical evidence and guideline recommendations for the application of HRT/SBRT in the treatment of breast, prostate, and lung cancers. It emphasizes the critical importance of rigorous training, technology, stringent quality assurance, and safety protocols to ensure precise and secure treatments. Additionally, it addresses practical considerations for implementing these treatments in LMICs, highlighting the need for comprehensive support and collaboration to enhance patient access to advanced cancer care.

Indexed as

hypofractionated radiotherapylow- and middle-income countries (LMICs)resource-limited settingsstereotactic body radiation therapytreatment duration optimization

Identifiers

PMID38339290
PMCPMC10854666

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.