Evidence map›Paper›PMID 38339232›Full record

ReviewCancers2024

Incorporating Novel Technologies in Precision Oncology for Colorectal Cancer: Advancing Personalized Medicine.

Pankaj Ahluwalia, Kalyani Ballur, Tiffanie Leeman, Ashutosh Vashisht, Harmanpreet Singh, Nivin Omar, Ashis K Mondal, Kumar Vaibhav, Babak Baban, Ravindra Kolhe

Abstract readReview
In one paragraph

Review in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Pankaj AhluwaliaDepartment of Pathology, Medical College of Georgia at Augusta University, Augusta, GA 30912, USA.ORCID 0000-0003-0060-6152
Kalyani BallurDepartment of Pathology, Medical College of Georgia at Augusta University, Augusta, GA 30912, USA.
Tiffanie LeemanDepartment of Pathology, Medical College of Georgia at Augusta University, Augusta, GA 30912, USA.
Ashutosh VashishtDepartment of Pathology, Medical College of Georgia at Augusta University, Augusta, GA 30912, USA.
Harmanpreet SinghDepartment of Pathology, Medical College of Georgia at Augusta University, Augusta, GA 30912, USA.
Nivin OmarDepartment of Pathology, Medical College of Georgia at Augusta University, Augusta, GA 30912, USA.
Ashis K MondalDepartment of Pathology, Medical College of Georgia at Augusta University, Augusta, GA 30912, USA.ORCID 0000-0003-3826-9489
Kumar VaibhavDepartment of Neurosurgery, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0002-4206-3830
Babak BabanDepartments of Neurology and Surgery, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0002-3144-2288
Ravindra KolheDepartment of Pathology, Medical College of Georgia at Augusta University, Augusta, GA 30912, USA.ORCID 0000-0002-8283-2403

Funding

August University Start-up grantPaceline Paceline Funding
6 · The paper itself

Abstract

Colorectal cancer (CRC) is one of the most heterogeneous and deadly diseases, with a global incidence of 1.5 million cases per year. Genomics has revolutionized the clinical management of CRC by enabling comprehensive molecular profiling of cancer. However, a deeper understanding of the molecular factors is needed to identify new prognostic and predictive markers that can assist in designing more effective therapeutic regimens for the improved management of CRC. Recent breakthroughs in single-cell analysis have identified new cell subtypes that play a critical role in tumor progression and could serve as potential therapeutic targets. Spatial analysis of the transcriptome and proteome holds the key to unlocking pathogenic cellular interactions, while liquid biopsy profiling of molecular variables from serum holds great potential for monitoring therapy resistance. Furthermore, gene expression signatures from various pathways have emerged as promising prognostic indicators in colorectal cancer and have the potential to enhance the development of equitable medicine. The advancement of these technologies for identifying new markers, particularly in the domain of predictive and personalized medicine, has the potential to improve the management of patients with CRC. Further investigations utilizing similar methods could uncover molecular subtypes specific to emerging therapies, potentially strengthening the development of personalized medicine for CRC patients.

Indexed as

clinicalcolorectal cancerequitable medicinegene signaturegenomicsimmune infiltrationimmunotherapy responsepersonalizedprecision medicinepredictivepreventiveprognosticspatialstratified medicine

Identifiers

PMID38339232
PMCPMC10854941

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.