Evidence map›Paper›PMID 38339229›Full record

ArticleCancers2024

Prediction of Patient Outcomes in Locally Advanced Cervical Carcinoma Following Chemoradiotherapy-Comparative Effectiveness of Magnetic Resonance Imaging and 2-Deoxy-2-[

Simran Singh Dhesi, Russell Frood, Sarah Swift, Rachel Cooper, Siddhant Muzumdar, Mehvish Jamal, Andrew Scarsbrook

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Simran Singh DhesiDepartment of Radiology, Leeds Teaching Hospitals NHS Trust, Leeds LS9 7TF, UK.
Russell FroodDepartment of Radiology, Leeds Teaching Hospitals NHS Trust, Leeds LS9 7TF, UK.ORCID 0000-0003-2681-9922
Sarah SwiftDepartment of Radiology, Leeds Teaching Hospitals NHS Trust, Leeds LS9 7TF, UK.
Rachel CooperDepartment of Clinical Oncology, Leeds Cancer Centre, Leeds LS9 7TF, UK.
Siddhant MuzumdarDepartment of Radiology, Chelsea & Westminster Hospital, 369 Fulham Rd., London SW10 9NH, UK.
Mehvish JamalDepartment of Radiology, Leeds Teaching Hospitals NHS Trust, Leeds LS9 7TF, UK.
Andrew ScarsbrookDepartment of Radiology, Leeds Teaching Hospitals NHS Trust, Leeds LS9 7TF, UK.ORCID 0000-0002-4243-032X
Leeds Teaching Hospitals NHS Trust · GBUniversity of Leeds · GBChelsea and Westminster Hospital · GB

Funding

Cancer Research UK 28832Cancer Research UK RCCCTF-OCT22/100002
6 · The paper itself

Abstract

purposeTo evaluate the utility and comparative effectiveness of three five-point qualitative scoring systems for assessing response on PET-CT and MRI imaging individually and in combination, following curative-intent chemoradiotherapy (CRT) in locally advanced cervical cancer (LACC). Their performance in the prediction of subsequent patient outcomes was also assessed; Methods: Ninety-seven patients with histologically confirmed LACC treated with CRT using standard institutional protocols at a single centre who underwent PET-CT and MRI at staging and post treatment were identified retrospectively from an institutional database. The post-CRT imaging studies were independently reviewed, and response assessed using five-point scoring tools for T2WI, DWI, and FDG PET-CT. Patient characteristics, staging, treatment, and follow-up details including progression-free survival (PFS) and overall survival (OS) outcomes were collected. To compare diagnostic performance metrics, a two-proportion z-test was employed. A Kaplan-Meier analysis (Mantel-Cox log-rank) was performed.

resultsThe T2WI (

conclusionPost-CRT response assessment using qualitative MR scoring and/or consensus PET-CT and MRI scoring was a better predictor of outcome compared to PET-CT assessment alone. This requires validation in a larger prospective study but offers the potential to help stratify patient follow-up in the future.

Indexed as

cervical cancerchemotherapydiffusion-weighted imagingMRIPET-CTradiotherapyrecurrence

Identifiers

PMID38339229
PMCPMC10854890
OpenAlexW4391136005

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.