Evidence map›Paper›PMID 38339228›Full record

ArticleCancers2024

Genetically Engineered Probiotic

Diala F Hamade, Michael W Epperly, Renee Fisher, Wen Hou, Donna Shields, Jan-Peter van Pijkeren, Brian J Leibowitz, Lan G Coffman, Hong Wang, M Saiful Huq and 5 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
3.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Living Microbial Drugs.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Diala F HamadeDepartment of Radiation Oncology, UPMC Hillman Cancer Center, Pittsburgh, PA 15232, USA.
Michael W EpperlyDepartment of Radiation Oncology, UPMC Hillman Cancer Center, Pittsburgh, PA 15232, USA.
Renee FisherDepartment of Radiation Oncology, UPMC Hillman Cancer Center, Pittsburgh, PA 15232, USA.
Wen HouDepartment of Radiation Oncology, UPMC Hillman Cancer Center, Pittsburgh, PA 15232, USA.
Donna ShieldsDepartment of Radiation Oncology, UPMC Hillman Cancer Center, Pittsburgh, PA 15232, USA.
Jan-Peter van PijkerenDepartment of Food Science, University of Wisconsin-Madison, Madison, WI 53706, USA.
Brian J LeibowitzDepartment of Radiation Oncology, UPMC Hillman Cancer Center, Pittsburgh, PA 15232, USA.
Lan G CoffmanDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Hong WangDepartment of Biostatistics, University of Pittsburgh, Pittsburgh, PA 15260, USA.
M Saiful HuqDepartment of Radiation Oncology, UPMC Hillman Cancer Center, Pittsburgh, PA 15232, USA.
Ziyu HuangDepartment of Biostatistics, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Claude J RogersChromoLogic, LLC, Monrovia, CA 91016, USA.
Anda M VladDivision of Cancer Prevention, National Cancer Institute, Rockville, MD 20850, USA.ORCID 0000-0001-5266-9695
Joel S GreenbergerDepartment of Radiation Oncology, UPMC Hillman Cancer Center, Pittsburgh, PA 15232, USA.ORCID 0000-0003-2271-7566
Amitava MukherjeeDepartment of Radiation Oncology, UPMC Hillman Cancer Center, Pittsburgh, PA 15232, USA.ORCID 0000-0001-5603-5147
UPMC Hillman Cancer Center · USUniversity of Pittsburgh · USChromoLogic (United States) · USNational Cancer Institute · USUniversity of Wisconsin–Madison · US

Funding

Training and EducationU19AI068021 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TYURINA, YULIA Y · 2005 to 2019
$44.4M
Development of second-generation probiotics as radiation mitigators75N93021C00008 · NIAID · CHROMOLOGIC, LLC · PI ROGERS, CLAUDE · 2021 to 2024
$2.7M
LR-IL-22 for Mitigation and Management of Radiation InjuriesU01AI172885 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JOEL S GREENBERGER · 2023 to 2026
$2.4M
NIAID NIH HHS 75N93021C00008NIAID NIH HHS U01 AI172885NIAID NIH HHS U19 AI068021
6 · The paper itself

Abstract

Despite recent advances in cancer therapy, ovarian cancer remains the most lethal gynecological cancer worldwide, making it crucial and of the utmost importance to establish novel therapeutic strategies. Adjuvant radiotherapy has been assessed historically, but its use was limited by intestinal toxicity. We recently established the role of

Indexed as

genetically engineeredLimosilactobacillus reuteriprobiotic

Identifiers

PMID38339228
PMCPMC10854600
OpenAlexW4391135988

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.