Evidence map›Paper›PMID 38339221›Full record

ArticleInternational journal of molecular sciences2024

Genetic Diversity in Bronchial Asthma Susceptibility: Exploring the Role of Vitamin D Receptor Gene Polymorphisms in Varied Geographic Contexts.

Natalia Paramonova, Ilva Trapina, Brigita Gradauskiene Sitkauskiene, Samanta Plavina, Laura Tamasauskiene, Daina Bastyte, Ingrida Rumba-Rozenfelde, Sandra Tapina, Ieva Stakaitiene, Rasa Ugenskiene and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Special Issue "Molecular Advances and Perspectives of Lung Disease".International journal of molecular sciences · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 3 countries.

Natalia ParamonovaLaboratory of Genomics and Bioinformatics, Institute of Biology, University of Latvia, LV-1004 Riga, Latvia.ORCID 0000-0001-6375-3331
Ilva TrapinaLaboratory of Genomics and Bioinformatics, Institute of Biology, University of Latvia, LV-1004 Riga, Latvia.ORCID 0000-0002-2165-4770
Brigita Gradauskiene SitkauskieneDepartment of Immunology and Allergology, Lithuanian University of Health Sciences, LT-50161 Kaunas, Lithuania.
Samanta PlavinaLaboratory of Genomics and Bioinformatics, Institute of Biology, University of Latvia, LV-1004 Riga, Latvia.ORCID 0009-0001-0984-4002
Laura TamasauskieneDepartment of Immunology and Allergology, Lithuanian University of Health Sciences, LT-50161 Kaunas, Lithuania.
Daina BastyteDepartment of Immunology and Allergology, Lithuanian University of Health Sciences, LT-50161 Kaunas, Lithuania.
Ingrida Rumba-RozenfeldeFaculty of Medicine, University of Latvia, LV-1586 Riga, Latvia.
Sandra TapinaFaculty of Medicine, University of Latvia, LV-1586 Riga, Latvia.
Ieva StakaitieneDepartment of Genetics and Molecular Medicine, Lithuanian University of Health Sciences, LT-50161 Kaunas, Lithuania.ORCID 0000-0003-2739-8576
Rasa UgenskieneDepartment of Genetics and Molecular Medicine, Lithuanian University of Health Sciences, LT-50161 Kaunas, Lithuania.
Lawrence Shih-Hsin WuGraduate Institute of Biomedical Sciences, China Medical University, Taichung 406040, Taiwan.
Jiu-Yao WangResearch Center of Allergy, Immunology, and Microbiome (AIM), China Medical University Hospital, Taichung 404327, Taiwan.ORCID 0000-0003-4540-9822
Miao-Hsi HsiehResearch Center of Allergy, Immunology, and Microbiome (AIM), China Medical University Hospital, Taichung 404327, Taiwan.
Pei-Chi ChenResearch Center of Allergy, Immunology, and Microbiome (AIM), China Medical University Hospital, Taichung 404327, Taiwan.
Nikolajs SjaksteLaboratory of Genomics and Bioinformatics, Institute of Biology, University of Latvia, LV-1004 Riga, Latvia.
University of Latvia · LVLithuanian University of Health Sciences · LTChina Medical University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bronchial asthma (BA) exhibits varying prevalence across global populations, prompting a comprehensive investigation into genetic and environmental determinants. Vitamin D is a potent immunomodulator capable of suppressing inflammatory signals in several cell types involved in the asthmatic response; it exerts effects on the immune system by binding to the nuclear vitamin D receptor (VDR). VDR gene genetic variations are affecting serum vitamin D levels with a possible role in the BA risk. The current study aimed to examine the complex interaction of various factors (genetic background, serum vitamin D levels, and geographic location) to identify differences in the influence of these factors on the susceptibility to asthma between populations at different latitudes. Focusing on Eastern European cohorts from Latvia and Lithuania and comparing them with published data on East Asian populations, we explore the impact of VDR gene polymorphisms on BA susceptibility. Genotyping four key

Indexed as

AsthmaReceptors, CalcitriolCase-Control StudiesGenetic Predisposition to DiseaseGenotypeHumansPolymorphism, Single NucleotideVitamin DReceptors, CalcitriolVitamin D25(OH)D levelApaIBmslbronchial asthmaFokIpolymorphismsTaqIvitamin Dvitamin D receptor

Identifiers

PMID38339221
PMCPMC10856277
OpenAlexW4391574870

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.