Evidence map›Paper›PMID 38339173›Full record

ArticleInternational journal of molecular sciences2024

The Pathogenic RET Val804Met Variant in Acromegaly: A New Clinical Phenotype?

Sabrina Chiloiro, Ettore Domenico Capoluongo, Flavia Costanza, Angelo Minucci, Antonella Giampietro, Amato Infante, Domenico Milardi, Claudio Ricciardi Tenore, Maria De Bonis, Simona Gaudino and 6 more

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Genes · 2025
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Sabrina ChiloiroDepartment of Translational Medicine and Surgery, Università Cattolica del Sacro, 00168 Rome, Italy.
Ettore Domenico CapoluongoDepartment of Molecular Medicine and Medical Biotechnology, Federico II University, 80138 Naples, Italy.
Flavia CostanzaDepartment of Translational Medicine and Surgery, Università Cattolica del Sacro, 00168 Rome, Italy.ORCID 0000-0002-0942-0496
Angelo MinucciUnit of Molecular Diagnostics and Genomics, Department of Laboratory Sciences and Infectious Diseases, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.ORCID 0000-0002-0833-4334
Antonella GiampietroDepartment of Translational Medicine and Surgery, Università Cattolica del Sacro, 00168 Rome, Italy.
Amato InfanteDepartment of Imaging, Radiation Therapy and Hematology, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario Agostino Gemelli, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00168 Rome, Italy.ORCID 0000-0003-4407-2631
Domenico MilardiDepartment of Translational Medicine and Surgery, Università Cattolica del Sacro, 00168 Rome, Italy.
Claudio Ricciardi TenoreUnit of Molecular Diagnostics and Genomics, Department of Laboratory Sciences and Infectious Diseases, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.
Maria De BonisUnit of Molecular Diagnostics and Genomics, Department of Laboratory Sciences and Infectious Diseases, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.
Simona GaudinoDepartment of Imaging, Radiation Therapy and Hematology, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario Agostino Gemelli, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00168 Rome, Italy.ORCID 0000-0003-1681-4343
Guido RindiSection of Anatomic Pathology, Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
Alessandro OliviDepartment of Neurosurgery, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, L.go A. Gemelli, 8, 00168 Rome, Italy.
Laura De MarinisDepartment of Translational Medicine and Surgery, Università Cattolica del Sacro, 00168 Rome, Italy.
Alfredo PontecorviDepartment of Translational Medicine and Surgery, Università Cattolica del Sacro, 00168 Rome, Italy.
Francesco DogliettoDepartment of Neurosurgery, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, L.go A. Gemelli, 8, 00168 Rome, Italy.ORCID 0000-0002-7438-0734
Antonio BianchiDepartment of Translational Medicine and Surgery, Università Cattolica del Sacro, 00168 Rome, Italy.
Università Cattolica del Sacro Cuore · ITAgostino Gemelli University Polyclinic · ITFederico II University Hospital · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several genetic investigations were conducted to identify germline and somatic mutations in somatotropinomas, a subtype of pituitary tumors. To our knowledge, we report the first acromegaly patient carrying a

Indexed as

AcromegalyProto-Oncogene Proteins c-retGerm-Line MutationHumansMultiple Endocrine Neoplasia Type 2aMutationPhenotypeThyroid NeoplasmsProto-Oncogene Proteins c-retRET protein, humanacromegalygeneticshereditary cancer-predisposing syndromeprecision medicineRET mutation

Identifiers

PMID38339173
PMCPMC10856706
OpenAlexW4391539836

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.