Evidence map›Paper›PMID 38339172›Full record

ArticleInternational journal of molecular sciences2024

Fuch's Endothelial Corneal Dystrophy in Cataract Patients Is Associated with Elevated Levels of Inflammatory Chemokines, but Not Growth Factors, in the Aqueous Humor.

Rafał Fiolka, Edward Wylęgała, Michał Toborek, Dominika Szkodny, Zenon Czuba, Adam Wylęgała

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.7field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Rafał FiolkaDepartment of Ophthalmology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-760 Katowice, Poland.ORCID 0000-0003-1573-9353
Edward WylęgałaDepartment of Ophthalmology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-760 Katowice, Poland.ORCID 0000-0002-6707-5790
Michał ToborekDepartment of Biochemistry and Molecular Biology, University of Miami School of Medicine, Miami, FL 33136, USA.ORCID 0000-0003-4475-2119
Dominika SzkodnyDepartment of Ophthalmology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-760 Katowice, Poland.ORCID 0000-0001-8120-7801
Zenon CzubaDepartment of Microbiology and Immunology, Faculty of Medical Science in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland.ORCID 0000-0001-8216-4495
Adam WylęgałaHealth Promotion and Obesity Management, Pathophysiology Department, Medical University of Silesia in Katowice, 40-752 Katowice, Poland.ORCID 0000-0001-7295-4936
Medical University of Silesia · PLUniversity of Miami · US

Funding

Medical University of Silesia PCN-2-063/N/2/O.
6 · The paper itself

Abstract

The study investigated a profile of chemokines and growth factors in the aqueous humor (AH) of eyes with Fuch's endothelial corneal dystrophy (FECD) and cataracts in comparison with cataract patients as a control group. A total of 52 AH samples (26 FECD + cataract and 26 cataract/control) were collected before cataract surgery. None of the patients had any clinically apparent inflammation at the time of AH collection. The AH levels of MCP-1 (CCL2), MIP-1α (CCL3), MIP-1β(CCL4), RANTES (CCL5), eotaxin (CCL11), IP-10 (CXCL10), FGF basic, G-CSF, GM-CSF, PDGF-bb, and VEGF were compared between the groups. The analyses were performed using the Bio-Plex 200 System from Bio-Rad. Among the studied parameters, the AH levels of RANTES, eotaxin, and IP-10 significantly increased in the FECD + cataract eyes, compared with the cataract controls (

Indexed as

CataractCorneal Dystrophies, HereditaryAqueous HumorChemokine CXCL10ChemokinesCytokinesHumansInflammationChemokine CXCL10ChemokinesCytokinescataracteotaxinFuch’s endothelial corneal dystrophyIP-10RANTESVEGF

Identifiers

PMID38339172
PMCPMC10856247
OpenAlexW4391533257

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.