ArticleInternational journal of molecular sciences2024
Cerebral Benefits Induced by Electrical Muscle Stimulation: Evidence from a Human and Rat Study.
Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 12 citations in OpenAlex.
- Trial
- Acute effects of neuromuscular electrical stimulation on lactate, IGF-1 and cognition in chronic spinal cord injury: A pilot randomized cross-over study.The journal of spinal cord medicine · 2026Trial
- The combination of low-intensity resistance exercise and electrical muscle stimulation effectively enhances executive function in men.Clinical physiology and functional imaging · 2026Trial
- High-intensity interval training differentially modulates acute BDNF and cognitive responses in young adult males: a randomized crossover trial.Scientific reports · 2026Trial
- Positive effects of functional electrical stimulation-assisted cycling on perception of effort, cerebral blood flow, and cognition in post-stroke patients.Journal of neuroengineering and rehabilitation · 2025Trial
- Cerebrovascular and cognitive responses to bilateral simultaneous versus unilateral alternating quadriceps electrical muscle stimulation in healthy young men.European journal of applied physiology · 2026Article
- Enhancement of Cerebral Oxygenation by Lower-Limb Neuromuscular Electrical Stimulation in Stroke Survivors.Annals of biomedical engineering · 2026Observational
- Article
- Electrical Stimulation-Induced Muscle Damage Alters Hippocampal BDNF Signaling.The European journal of neuroscience · 2025Article
- Optimised Skeletal Muscle Mass as a Key Strategy for Obesity Management.Metabolites · 2025Review
- Electrical stimulation: a potential alternative to positively impact cerebral health?Frontiers in physiology · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Physical exercise (EX) is well established for its positive impact on brain health. However, conventional EX may not be feasible for certain individuals. In this regard, this study explores electromyostimulation (EMS) as a potential alternative for enhancing cognitive function. Conducted on both human participants and rats, the study involved two sessions of EMS applied to the quadriceps with a duration of 30 min at one-week intervals. The human subjects experienced assessments of cognition and mood, while the rats underwent histological and biochemical analyses on the prefrontal cortex, hippocampus, and quadriceps. Our findings indicated that EMS enhanced executive functions and reduced anxiety in humans. In parallel, our results from the animal studies revealed an elevation in brain-derived neurotrophic factor (BDNF), specifically in the hippocampus. Intriguingly, this increase was not associated with heightened neuronal activity or cerebral hemodynamics; instead, our data point towards a humoral interaction from muscle to brain. While no evidence of increased muscle and circulating BDNF or FNDC5/irisin pathways could be found, our data highlight lactate as a bridging signaling molecule of the muscle-brain crosstalk following EMS. In conclusion, our results suggest that EMS could be an effective alternative to conventional EX for enhancing both brain health and cognitive function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.