Evidence map›Paper›PMID 38339143›Full record

ArticleInternational journal of molecular sciences2024

Decreased Expression of Placental Proteins in Recurrent Pregnancy Loss: Functional Relevance and Diagnostic Value.

Eszter Tóth, Dániel Györffy, Máté Posta, Petronella Hupuczi, Andrea Balogh, Gábor Szalai, Gergő Orosz, László Orosz, András Szilágyi, Orsolya Oravecz and 8 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. PAPPA's role in female reproduction.Reproduction (Cambridge, England) · 2025
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 9 institutions in 4 countries.

Eszter TóthSystems Biology of Reproduction Research Group, Institute of Molecular Life Sciences, HUN-REN Research Centre for Natural Sciences, Magyar Tudósok Körútja 2, H-1117 Budapest, Hungary.ORCID 0000-0001-7149-1482
Dániel GyörffySystems Biology of Reproduction Research Group, Institute of Molecular Life Sciences, HUN-REN Research Centre for Natural Sciences, Magyar Tudósok Körútja 2, H-1117 Budapest, Hungary.ORCID 0009-0006-3301-5542
Máté PostaSystems Biology of Reproduction Research Group, Institute of Molecular Life Sciences, HUN-REN Research Centre for Natural Sciences, Magyar Tudósok Körútja 2, H-1117 Budapest, Hungary.
Petronella HupucziMaternity Private Clinic of Obstetrics and Gynecology, H-1126 Budapest, Hungary.
Andrea BaloghSystems Biology of Reproduction Research Group, Institute of Molecular Life Sciences, HUN-REN Research Centre for Natural Sciences, Magyar Tudósok Körútja 2, H-1117 Budapest, Hungary.ORCID 0000-0003-0322-1522
Gábor SzalaiSystems Biology of Reproduction Research Group, Institute of Molecular Life Sciences, HUN-REN Research Centre for Natural Sciences, Magyar Tudósok Körútja 2, H-1117 Budapest, Hungary.
Gergő OroszDepartment of Obstetrics and Gynecology, Medical School, University of Debrecen, H-4032 Debrecen, Hungary.
László OroszDepartment of Obstetrics and Gynecology, Medical School, University of Debrecen, H-4032 Debrecen, Hungary.ORCID 0000-0003-1563-8579
András SzilágyiSystems Biology of Reproduction Research Group, Institute of Molecular Life Sciences, HUN-REN Research Centre for Natural Sciences, Magyar Tudósok Körútja 2, H-1117 Budapest, Hungary.ORCID 0000-0002-1773-6861
Orsolya OraveczSystems Biology of Reproduction Research Group, Institute of Molecular Life Sciences, HUN-REN Research Centre for Natural Sciences, Magyar Tudósok Körútja 2, H-1117 Budapest, Hungary.ORCID 0000-0002-7342-183X
Lajos VeressDepartment of Pharmacology and Pharmacotherapy, Medical School, University of Debrecen, H-4032 Debrecen, Hungary.
Sándor NagyFaculty of Health and Sport Sciences, Széchenyi István University, H-9026 Győr, Hungary.ORCID 0000-0002-7054-8333
Olga TörökDepartment of Obstetrics and Gynecology, Medical School, University of Debrecen, H-4032 Debrecen, Hungary.
Padma MurthiDepartment of Pharmacology, Monash Biomedicine Discovery Institute, Clayton 3168, Australia.ORCID 0000-0003-2535-5134
Offer ErezDepartment of Obstetrics and Gynecology, Soroka University Medical Center, Ben Gurion University of the Negev, Be'er Sheva 8410501, Israel.
Zoltán PappMaternity Private Clinic of Obstetrics and Gynecology, H-1126 Budapest, Hungary.
Nándor ÁcsDepartment of Obstetrics and Gynecology, Medical School, Semmelweis University, 27 Baross Street, H-1088 Budapest, Hungary.ORCID 0000-0002-1919-1869
Nándor Gábor ThanSystems Biology of Reproduction Research Group, Institute of Molecular Life Sciences, HUN-REN Research Centre for Natural Sciences, Magyar Tudósok Körútja 2, H-1117 Budapest, Hungary.
Semmelweis University · HUUniversity of Debrecen · HUHUN-REN Research Centre for Natural Sciences · HUBen-Gurion University of the Negev · ILEötvös Loránd University · HUPázmány Péter Catholic University · HURoyal Women's Hospital · AUSzéchenyi István University · HUUniversity of Pecs · HU

Funding

Hungarian Academy of Sciences Momentum LP2014-7/2014, Premium_2019-436, Young Research FellowshipHungarian Research Network HUN-REN SA-83/2021Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund FIEK-16-1-2016-0005, K124862, K128262, 2020-1.1.2-PIACI-KFI-2021-00273 and 2019-2.1.7-ERANET-2020-00014 funding schemes, the latter under the frame of European Union ERA PerMed (2020-346 grant)
6 · The paper itself

Abstract

Miscarriages affect 50-70% of all conceptions and 15-20% of clinically recognized pregnancies. Recurrent pregnancy loss (RPL, ≥2 miscarriages) affects 1-5% of recognized pregnancies. Nevertheless, our knowledge about the etiologies and pathophysiology of RPL is incomplete, and thus, reliable diagnostic/preventive tools are not yet available. Here, we aimed to define the diagnostic value of three placental proteins for RPL: human chorionic gonadotropin free beta-subunit (free-β-hCG), pregnancy-associated plasma protein-A (PAPP-A), and placental growth factor (PlGF). Blood samples were collected from women with RPL (

Indexed as

Abortion, HabitualPregnancy ProteinsBiomarkersBlood ProteinsChorionic Gonadotropin, beta Subunit, HumanFemaleHumansPlacentaPlacenta Growth FactorPregnancyPregnancy-Associated Plasma Protein-APregnancy Trimester, FirstBiomarkersBlood ProteinsChorionic Gonadotropin, beta Subunit, HumanPlacenta Growth FactorPregnancy-Associated Plasma Protein-APregnancy Proteinsbioinformaticshabitual abortionliquid biopsynon-invasive monitoringplacental proteinprenatal diagnosticsrecurrent miscarriagespontaneous abortion

Identifiers

PMID38339143
PMCPMC10855863
OpenAlexW4391539784

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.