Evidence map›Paper›PMID 38339062›Full record

ArticleInternational journal of molecular sciences2024

Transcriptome Analysis Reveals Anti-Cancer Effects of Isorhapontigenin (ISO) on Highly Invasive Human T24 Bladder Cancer Cells.

Alex H Li, Sun Young Park, Peiwei Li, Chaoting Zhou, Thomas Kluz, Jingxia Li, Max Costa, Hong Sun

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Alex H LiDivision of Environmental Medicine, Department of Medicine, NYU Grossman School of Medicine, 341 East 25th Street, New York, NY 10010, USA.
Sun Young ParkDivision of Environmental Medicine, Department of Medicine, NYU Grossman School of Medicine, 341 East 25th Street, New York, NY 10010, USA.
Peiwei LiDivision of Environmental Medicine, Department of Medicine, NYU Grossman School of Medicine, 341 East 25th Street, New York, NY 10010, USA.
Chaoting ZhouDivision of Environmental Medicine, Department of Medicine, NYU Grossman School of Medicine, 341 East 25th Street, New York, NY 10010, USA.
Thomas KluzDivision of Environmental Medicine, Department of Medicine, NYU Grossman School of Medicine, 341 East 25th Street, New York, NY 10010, USA.
Jingxia LiDivision of Environmental Medicine, Department of Medicine, NYU Grossman School of Medicine, 341 East 25th Street, New York, NY 10010, USA.
Max CostaDivision of Environmental Medicine, Department of Medicine, NYU Grossman School of Medicine, 341 East 25th Street, New York, NY 10010, USA.
Hong SunDivision of Environmental Medicine, Department of Medicine, NYU Grossman School of Medicine, 341 East 25th Street, New York, NY 10010, USA.ORCID 0000-0002-9885-4797
New York University · US

Funding

Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MARK Reid PHILIPS · 1985 to 2026
$83.1M
TRAINING PROGRAM IN ENVIRONMENTAL TOXICOLOGYT32ES007324 · NIEHS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CUDDAPAH, SURESH · 1999 to 2025
$5.8M
SESN2 and therapeutic effect of Isohapontigenin (ISO)R01CA217923 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI COSTA, MAX, SUN, HONG · 2018 to 2022
$2.1M
ALKBH5 and nickel-induced lung carcinogenesisR21ES034811 · NIEHS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SUN, HONG · 2023 to 2024
$466k
NCI NIH HHS P30 CA016087NCI NIH HHS R01 CA217923NIEHS NIH HHS R21 ES034811NIEHS NIH HHS T32 ES007324
6 · The paper itself

Abstract

Bladder cancer, the most common malignancy of the urinary tract, has a poor overall survival rate when the tumor becomes muscle invasive. The discovery and evaluation of new alternative medications targeting high-grade muscle invasive bladder cancer (MIBC) are of tremendous importance in reducing bladder cancer mortality. Isorhapontigenin (ISO), a stilbene derivative from the Chinese herb

Indexed as

StilbenesUrinary Bladder NeoplasmsCell Line, TumorGene Expression ProfilingGene Expression Regulation, NeoplasticHumansTranscriptomeTumor MicroenvironmentisorhapontigeninStilbenesactin cytoskeletonbladder cancermetabolic reprogrammingtumor microenvironmentwhole transcriptome analysis

Identifiers

PMID38339062
PMCPMC10855786
OpenAlexW4391449941

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.