Evidence map›Paper›PMID 38339011›Full record

ArticleInternational journal of molecular sciences2024

Joint CB1 and NGF Receptor Activation Suppresses TRPM8 Activation in Etoposide-Resistant Retinoblastoma Cells.

Szymon Ludwiczak, Jacqueline Reinhard, Peter S Reinach, Aruna Li, Jakub Oronowicz, Aisha Yousf, Vinodh Kakkassery, Stefan Mergler

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Medical Cannabis and the Hallmarks of Cancer: A Critical Narrative Review.International journal of molecular sciences · 2026
    Review
  2. Review
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  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Szymon LudwiczakDepartment of Ophthalmology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin, Germany.
Jacqueline ReinhardDepartment of Cell Morphology and Molecular Neurobiology, Faculty of Biology and Biotechnology, Ruhr University Bochum, 44801 Bochum, Germany.
Peter S ReinachSchool of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou 325015, China.
Aruna LiDepartment of Ophthalmology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin, Germany.
Jakub OronowiczMalteser Waldkrankenhaus Clinic for Orthopedics and Trauma Surgery, 91054 Erlangen, Germany.
Aisha YousfDepartment of Cell Morphology and Molecular Neurobiology, Faculty of Biology and Biotechnology, Ruhr University Bochum, 44801 Bochum, Germany.
Vinodh KakkasseryDepartment of Ophthalmology, Clinic Chemnitz, 09116 Chemnitz, Germany.ORCID 0000-0001-6212-8964
Stefan MerglerDepartment of Ophthalmology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin, Germany.ORCID 0000-0001-8608-648X
Humboldt-Universität zu Berlin · DERuhr University Bochum · DEMalteser Waldkrankenhaus Erlangen · DEOphthalmology Clinic · DEWenzhou Medical University · CN

Funding

Berliner Sonnfeld-Stiftung not givenDeutsche Forschungsgemeinschaft ME 1706/18-1KinderAugenKrebsStiftung KAKS2019118f-UKL
6 · The paper itself

Abstract

In childhood, retinoblastoma (RB) is the most common primary tumor in the eye. Long term therapeutic management with etoposide of this life-threatening condition may have diminishing effectiveness since RB cells can develop cytostatic resistance to this drug. To determine whether changes in receptor-mediated control of Ca

Indexed as

Receptor, Nerve Growth FactorRetinal NeoplasmsRetinoblastomaTRPM Cation ChannelsCell LineEtoposideHumansMembrane ProteinsReceptor, Cannabinoid, CB1EtoposideMembrane ProteinsReceptor, Cannabinoid, CB1Receptor, Nerve Growth FactorTRPM8 channel-associated factor 1 protein, humanTRPM8 protein, humanTRPM Cation ChannelsCa2+ signalingcannabinoid receptor 1chemotherapy resistanceetoposidenerve growth factorretinoblastomatransient receptor potential channel melastatin 8transient receptor potential channel vanilloid 1

Identifiers

PMID38339011
PMCPMC10855132
OpenAlexW4391435076

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.