Evidence map›Paper›PMID 38338968›Full record

ArticleInternational journal of molecular sciences2024

The WMI Rat of Premature Cognitive Aging Presents Intrinsic Vulnerability to Oxidative Stress in Primary Neurons and Astrocytes Compared to Its Nearly Isogenic WLI Control.

Adriana Ferreira, Aspen Harter, Sana Afreen, Karoly Kanai, Sandor Batori, Eva E Redei

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Adriana FerreiraDepartment of Cell and Developmental Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Aspen HarterDepartment of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Sana AfreenDepartment of Cell and Developmental Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Karoly KanaiDepartment of Organic Chemistry and Technology, Budapest University of Technology and Economics, 1111 Budapest, Hungary.ORCID 0009-0008-8597-6358
Sandor BatoriDepartment of Organic Chemistry and Technology, Budapest University of Technology and Economics, 1111 Budapest, Hungary.
Eva E RedeiDepartment of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Northwestern University · USBudapest University of Technology and Economics · HU

Funding

Davee Foundation N/ANorthwestern University Weinberg College of Arts and Sciences N/A
6 · The paper itself

Abstract

The primary neuronal and astrocyte culture described here is from the stress-hyperreactive Wistar Kyoto (WKY) More Immobile (WMI) rat with premature aging-related memory deficit, and its nearly isogenic control, the Less Immobile (WLI) strain. Primary WMI hippocampal neurons and cortical astrocytes are significantly more sensitive to oxidative stress (OS) generated by administration of H

Indexed as

Aging, PrematureCognitive AgingAnimalsAstrocytesCells, CulturedHydrogen PeroxideNeuronsOxidative StressPilot ProjectsRatsRats, Inbred WKYHydrogen Peroxidegene expressionsmitochondrial dysfunctionoxidative stressstrain differences

Identifiers

PMID38338968
PMCPMC10855588
OpenAlexW4391351989

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.