Evidence map›Paper›PMID 38338900›Full record

ArticleInternational journal of molecular sciences2024

A Comparative Pharmacokinetic Study for Cysteamine-Containing Eye Drops as an Orphan Topical Therapy in Cystinosis.

Anita Csorba, Gábor Katona, Mária Budai-Szűcs, Diána Balogh-Weiser, Péter Molnár, Erika Maka, Adrienn Kazsoki, Márton Vajna, Romána Zelkó, Zoltán Zsolt Nagy and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 98% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Anita CsorbaDepartment of Ophthalmology, Semmelweis University, Mária Street 39, H-1085 Budapest, Hungary.
Gábor KatonaInstitute of Pharmaceutical Technology and Regulatory Affairs, Faculty of Pharmacy, University of Szeged, Eötvös Street 6, H-6720 Szeged, Hungary.ORCID 0000-0003-1564-4813
Mária Budai-SzűcsInstitute of Pharmaceutical Technology and Regulatory Affairs, Faculty of Pharmacy, University of Szeged, Eötvös Street 6, H-6720 Szeged, Hungary.ORCID 0000-0001-5187-5702
Diána Balogh-WeiserDepartment of Physical Chemistry and Materials Science, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3, H-1111 Budapest, Hungary.ORCID 0000-0002-9957-1203
Péter MolnárMolteam Llc., Mélyfúró Street 4, H-1151 Budapest, Hungary.
Erika MakaDepartment of Ophthalmology, Semmelweis University, Mária Street 39, H-1085 Budapest, Hungary.ORCID 0000-0002-3631-3506
Adrienn KazsokiUniversity Pharmacy Department of Pharmacy Administration, Semmelweis University, Hőgyes Endre Street 7-9, H-1092 Budapest, Hungary.
Márton VajnaUniversity Pharmacy Department of Pharmacy Administration, Semmelweis University, Hőgyes Endre Street 7-9, H-1092 Budapest, Hungary.
Romána ZelkóUniversity Pharmacy Department of Pharmacy Administration, Semmelweis University, Hőgyes Endre Street 7-9, H-1092 Budapest, Hungary.ORCID 0000-0002-5419-9137
Zoltán Zsolt NagyDepartment of Ophthalmology, Semmelweis University, Mária Street 39, H-1085 Budapest, Hungary.
György T BaloghDepartment of Pharmaceutical Chemistry, Semmelweis University, Hőgyes Endre Street 7-9, H-1092 Budapest, Hungary.ORCID 0000-0001-8273-1760
Semmelweis University · HUUniversity of Szeged · HUBudapest University of Technology and Economics · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cystinosis is a low-prevalence lysosomal storage disease. The pathomechanism involves abnormal functioning of the cystinosine lysosomal cystine transporter (CTNS), causing intraliposomal accumulation of the amino acid cysteine disulfide, which crystallizes and deposits in several parts of the body. The most common ophthalmic complication of cystinosis is the deposition of "gold dust" cystine crystals on the cornea, which already occurs in infancy and leads to severe photosensitivity and dry eyes as it gradually progresses with age. In the specific treatment of cystinosis, preparations containing cysteamine (CYA) are used. The availability of commercialized eyedrops for the targeted treatment is scarce, and only Cystadrops

Indexed as

CystinosisCorneaCysteamineCystineHumansOphthalmic SolutionsCysteamineCystineOphthalmic Solutionscorneal permeabilitycysteaminecystinosisin vitro and ex vivo studyphysicochemical characterization

Identifiers

PMID38338900
PMCPMC10855117
OpenAlexW4391317231

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.