ReviewInternational journal of molecular sciences2024
Nonspecific Orbital Inflammation (NSOI): Unraveling the Molecular Pathogenesis, Diagnostic Modalities, and Therapeutic Interventions.
Review in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Painful acute esotropia as a presenting sign of presumed post-infectious orbital myositis in a child: a case report.BMC ophthalmology · 2026Article
- Tocilizumab as an effective treatment option for idiopathic orbital inflammation: a case report and literature review.International journal of ophthalmology · 2026Article
- Unusual Presentation of Orbital Cellulitis as an Inflammatory Pseudotumor in a Kidney Transplant Recipient.Kidney medicine · 2025Article
- Integrated multiple machine learning and Mendelian randomization reveal LTF gene as a prognostic biomarker for nonspecific orbital inflammation.BMC pharmacology & toxicology · 2025Article
- Gluconeogenesis related gene signatures as biomarkers for nonspecific orbital inflammation.Scientific reports · 2025Article
- Molecular insights into ulcerative colitis and orbital inflammation.Scientific reports · 2025Article
- The Relevance and Potential Role of Orbital Fat in Inflammatory Orbital Diseases: Implications for Diagnosis and Treatment.Ophthalmology and therapy · 2025Review
- Immune Regulation and ECM-Related Pathway Enrichment Reveal ATP2A3 as a Prognostic Biomarker for Nonspecific Orbital Inflammation: An Integrated Machine Learning and Mendelian Randomization Analysis.Mediators of inflammation · 2025Article
- New Clues to the Pathogenesis of Idiopathic Orbital Inflammation: Elevated IL-8 and MCP-1 in Tear Fluid.Journal of ophthalmology · 2025Article
- Article
- Treatment Outcomes of Patients with Orbital Inflammatory Diseases: Should Steroids Still Be the First Choice?Journal of clinical medicine · 2024Article
- Guidelines for the standardized diagnosis and treatment of non-specific orbital inflammation (2024).International journal of ophthalmology · 2024Article
- Bone destruction of orbital wall in idiopathic orbital inflammatory pseudotumor: does it always imply malignancy?International journal of ophthalmology · 2024Article
- Idiopathic Posterior Scleritis Complicated by Optic Perineuritis and Ocular Motility Disorder Successfully Controlled with Adalimumab: A Case Report.Case reports in ophthalmologyArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nonspecific orbital inflammation (NSOI), colloquially known as orbital pseudotumor, sometimes presents a diagnostic and therapeutic challenge in ophthalmology. This review aims to dissect NSOI through a molecular lens, offering a comprehensive overview of its pathogenesis, clinical presentation, diagnostic methods, and management strategies. The article delves into the underpinnings of NSOI, examining immunological and environmental factors alongside intricate molecular mechanisms involving signaling pathways, cytokines, and mediators. Special emphasis is placed on emerging molecular discoveries and approaches, highlighting the significance of understanding molecular mechanisms in NSOI for the development of novel diagnostic and therapeutic tools. Various diagnostic modalities are scrutinized for their utility and limitations. Therapeutic interventions encompass medical treatments with corticosteroids and immunomodulatory agents, all discussed in light of current molecular understanding. More importantly, this review offers a novel molecular perspective on NSOI, dissecting its pathogenesis and management with an emphasis on the latest molecular discoveries. It introduces an integrated approach combining advanced molecular diagnostics with current clinical assessments and explores emerging targeted therapies. By synthesizing these facets, the review aims to inform clinicians and researchers alike, paving the way for molecularly informed, precision-based strategies for managing NSOI.
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Registered trials
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