Evidence map›Paper›PMID 38338807›Full record

ArticleInternational journal of molecular sciences2024

Abietic Acid as a Novel Agent against Ocular Biofilms: An In Vitro and Preliminary In Vivo Investigation.

Monika Dzięgielewska, Marzenna Bartoszewicz, Marta Książczyk, Bartłomiej Dudek, Malwina Brożyna, Patrycja Szymczyk-Ziółkowska, Piotr Gruber, Jacek Pawlak, Weronika Kozłowska, Sylwia Zielińska and 3 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Monika DzięgielewskaEye Institute, Prymasa Augusta Hlonda 10c/u7, 02-972 Warsaw, Poland.
Marzenna BartoszewiczDepartment of Pharmaceutical Microbiology and Parasitology, Medical University of Wroclaw, 50-367 Wroclaw, Poland.
Marta KsiążczykDepartment of Microbiology, Institute of Genetics and Microbiology, University of Wrocław, 51-148 Wroclaw, Poland.
Bartłomiej DudekPlatform for Unique Model Application, Department of Pharmaceutical Microbiology and Parasitology, Medical University of Wroclaw, 50-367 Wroclaw, Poland.
Malwina BrożynaPlatform for Unique Model Application, Department of Pharmaceutical Microbiology and Parasitology, Medical University of Wroclaw, 50-367 Wroclaw, Poland.ORCID 0000-0001-9520-3377
Patrycja Szymczyk-ZiółkowskaCenter for Advanced Manufacturing Technologies (CAMT/FPC), Faculty of Mechanical Engineering, Wroclaw University of Science and Technology, Łukasiewicza 5, 50-371 Wroclaw, Poland.ORCID 0000-0001-7742-7182
Piotr GruberCenter for Advanced Manufacturing Technologies (CAMT/FPC), Faculty of Mechanical Engineering, Wroclaw University of Science and Technology, Łukasiewicza 5, 50-371 Wroclaw, Poland.ORCID 0000-0001-7236-6763
Jacek PawlakMedical Department, Lazarski University, 02-662 Warsaw, Poland.
Weronika KozłowskaDepartment of Pharmaceutical Biology and Biotechnology, Division of Pharmaceutical Biotechnology, Wroclaw Medical University, 50-556 Wroclaw, Poland.
Sylwia ZielińskaDepartment of Pharmaceutical Biology and Biotechnology, Division of Pharmaceutical Biotechnology, Wroclaw Medical University, 50-556 Wroclaw, Poland.
Jędrzej FischerDepartment of Angiology, Hypertension and Diabetology, Wroclaw Medical University, 50-556 Wroclaw, Poland.ORCID 0000-0001-8872-6639
Aleksandra WoytońPlatform for Unique Model Application, Department of Pharmaceutical Microbiology and Parasitology, Medical University of Wroclaw, 50-367 Wroclaw, Poland.
Adam JunkaPlatform for Unique Model Application, Department of Pharmaceutical Microbiology and Parasitology, Medical University of Wroclaw, 50-367 Wroclaw, Poland.ORCID 0000-0002-7559-8903
University of Wrocław · PLWroclaw Medical University · PLWrocław University of Science and Technology · PLUczelnia Łazarskiego · PL

Funding

Wroclaw Medical University SUBZ.D230.23.030
6 · The paper itself

Abstract

Biofilm-related ocular infections can lead to vision loss and are difficult to treat with antibiotics due to challenges with application and increasing microbial resistance. In turn, the design and testing of new synthetic drugs is a time- and cost-consuming process. Therefore, in this work, for the first time, we assessed the in vitro efficacy of the plant-based abietic acid molecule, both alone and when introduced to a polymeric cellulose carrier, against biofilms formed by

Indexed as

Eye InfectionsMothsAbietanesAnimalsAnti-Bacterial AgentsBiofilmsLarvaMicrobial Sensitivity TestsStaphylococcusAbietanesabietic acidAnti-Bacterial Agentsabietic acidbacterial cellulosebiofilmGalleria mellonellaocular infectionspathogens

Identifiers

PMID38338807
PMCPMC10855443
OpenAlexW4391271958

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.