Evidence map›Paper›PMID 38338803›Full record

ArticleInternational journal of molecular sciences2024

Longitudinal NMR-Based Metabolomics Study Reveals How Hospitalized COVID-19 Patients Recover: Evidence of Dyslipidemia and Energy Metabolism Dysregulation.

Laura Ansone, Vita Rovite, Monta Brīvība, Lauma Jagare, Līva Pelcmane, Daniella Borisova, Anne Thews, Roland Leiminger, Jānis Kloviņš

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Comparative urinary metabolomics reveals unique and shared pathways in COVID-19 and liver diseases.Metabolomics : Official journal of the Metabolomic Society · 2026
    Article
  4. Review
  5. Review
  6. UrinaryMetabolites · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Laura AnsoneLatvian Biomedical Research and Study Centre, LV-1067 Riga, Latvia.ORCID 0000-0002-4684-9566
Vita RoviteLatvian Biomedical Research and Study Centre, LV-1067 Riga, Latvia.
Monta BrīvībaLatvian Biomedical Research and Study Centre, LV-1067 Riga, Latvia.
Lauma JagareLatvian Biomedical Research and Study Centre, LV-1067 Riga, Latvia.
Līva PelcmaneLatvian Biomedical Research and Study Centre, LV-1067 Riga, Latvia.
Daniella BorisovaLatvian Biomedical Research and Study Centre, LV-1067 Riga, Latvia.
Anne ThewsBruker BioSpin GmbH & Co., Rudolf-Plank-Straße 23, 76275 Ettlingen, Germany.
Roland LeimingerBruker BioSpin GmbH & Co., Rudolf-Plank-Straße 23, 76275 Ettlingen, Germany.
Jānis KloviņšLatvian Biomedical Research and Study Centre, LV-1067 Riga, Latvia.ORCID 0000-0001-8362-5505

Funding

European Regional Development Fund 1.1.1.1/21/A/029
6 · The paper itself

Abstract

Long COVID, or post-acute sequelae of SARS-CoV-2 infection (PASC), can manifest as long-term symptoms in multiple organ systems, including respiratory, cardiovascular, neurological, and metabolic systems. In patients with severe COVID-19, immune dysregulation is significant, and the relationship between metabolic regulation and immune response is of great interest in determining the pathophysiological mechanisms. We aimed to characterize the metabolomic footprint of recovering severe COVID-19 patients at three consecutive timepoints and compare metabolite levels to controls. Our findings add proof of dysregulated amino acid metabolism in the acute phase and dyslipidemia, glycoprotein level alterations, and energy metabolism disturbances in severe COVID-19 patients 3-4 months post-hospitalization.

Indexed as

COVID-19DyslipidemiasEnergy MetabolismHumansPost-Acute COVID-19 SyndromeSARS-CoV-2COVID-19dyslipidemiametabolomicsnuclear magnetic resonancepost-acute sequelae of SARS-CoV-2 infectionpost-COVID-19 conditionpost-COVID-19 syndromeSARS-CoV-2

Identifiers

PMID38338803
PMCPMC10855192

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.